UniProt O35298
Acyloxyacyl hydrolase (O35298)
Acyloxyacyl hydrolase (UniProt O35298), EC 3.1.1.77: 6 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O35298
- Protein
- Acyloxyacyl hydrolase
- EC
- 3.1.1.77
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 20 · 2 records with a druggable one
Structures
7 records of O35298 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5W7D | Murine acyloxyacyl hydrolase (AOAH), S262A mutant | x-ray diffraction | A | NAG, CA, PX8, MYR | — |
| 5W7D | Murine acyloxyacyl hydrolase (aoah), S262A mutant | x-ray diffraction | A | NAG, CA, PX8, MYR | — |
| 5W7E | Murine acyloxyacyl hydrolase (AOAH), S262A mutant, with dimyristoyl phosphatidylcholine | x-ray diffraction | A, B | CA, NAG, FAW | 11 (best 0.77) |
| 5W7E | Murine acyloxyacyl hydrolase (aoah), S262A mutant, with dimyristoyl phosphatidylcholine | x-ray diffraction | A, B | CA, NAG, FAW | — |
| 5W7F | Murine acyloxyacyl hydrolase (AOAH), S262A mutant, with lipid A | x-ray diffraction | A, B | CA, NAG, FTT, DAO, GCS | 9 (best 0.77) |
| 5W7F | Murine acyloxyacyl hydrolase (aoah), S262A mutant, with lipid a | x-ray diffraction | A, B | CA, NAG, FTT, DAO, GCS | — |
| O35298 | AlphaFold monomer V2.0 prediction for acyloxyacyl hydrolase (O35298) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 6 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 6 records
- DAO · Lauric acid · in 2 records
- FAW · (2S)-3-hydroxypropane-1,2-diyl ditetradecanoate · in 2 records
- FTT · 3-hydroxy-tetradecanoic acid · in 2 records
- GCS · 2-amino-2-deoxy-beta-D-glucopyranose · in 2 records
- MYR · Myristic acid · in 2 records
- PX8 · 1,2-distearoyl-sn-glycero-3-phosphate · in 2 records
Experiment against prediction
- 5W7D chain A against the predicted model O35298: TM-score 1.00, RMSD 0.67 Å
- 5W7D chain A against the predicted model O35298: TM-score 1.00, RMSD 0.67 Å
- 5W7E chain A against the predicted model O35298: TM-score 0.98, RMSD 1.70 Å
- 5W7E chain A against the predicted model O35298: TM-score 0.98, RMSD 1.70 Å
- 5W7F chain A against the predicted model O35298: TM-score 0.98, RMSD 1.73 Å
- 5W7F chain A against the predicted model O35298: TM-score 0.98, RMSD 1.73 Å
- 5W7E chain B against the predicted model O35298: TM-score 0.98, RMSD 1.84 Å
- 5W7E chain B against the predicted model O35298: TM-score 0.98, RMSD 1.84 Å
- 5W7F chain B against the predicted model O35298: TM-score 0.97, RMSD 1.76 Å
- 5W7F chain B against the predicted model O35298: TM-score 0.97, RMSD 1.76 Å
Elsewhere
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