UniProt O33336
4'-phosphopantetheinyl transferase PptT (O33336)
4'-phosphopantetheinyl transferase PptT (UniProt O33336), EC 2.7.8.7: 14 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O33336
- Protein
- 4'-phosphopantetheinyl transferase PptT
- EC
- 2.7.8.7
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 18 · 5 records with a druggable one
Structures
15 records of O33336 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4QJK | Crystal structure of M. tuberculosis phosphopantetheinyl transferase PptT | x-ray diffraction | A | — | — |
| 4QJK | Crystal structure of M. tuberculosis phosphopantetheinyl transferase pptt | x-ray diffraction | A | — | — |
| 4QVH | Crystal structure of the essential Mycobacterium tuberculosis phosphopantetheinyl transferase PptT… | x-ray diffraction | A, B | — | — |
| 4QVH | Crystal structure of the essential mycobacterium tuberculosis phosphopantetheinyl transferase pptt… | x-ray diffraction | A, B | — | — |
| 4U89 | 4'-phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis | x-ray diffraction | A | — | — |
| 4U89 | 4'-phosphopantetheinyl transferase pptt from mycobacterium tuberculosis | x-ray diffraction | A | — | — |
| 7N8E | PptT PAP(CoA) 9056 complex | x-ray diffraction | A, B | COA, MG, 0UD | 2 (best 0.77) |
| 7N8E | Pptt PAP(COA) 9056 complex | x-ray diffraction | A, B | COA, MG, 0UD | — |
| 7N8L | PptT PAP(CoA) 9016 complex | x-ray diffraction | A, B | COA, 10I, MG | — |
| 7N8L | Pptt PAP(COA) 9016 complex | x-ray diffraction | A, B | COA, 10I, MG | — |
| 7N8M | Pptt PAP(COA) 8978B complex | x-ray diffraction | A, B | COA, 17I, MG | — |
| 8QZH | Crystal structure of apo-PptT from Mycobacterium tuberculosis | x-ray diffraction | A | MG | 1 (best 0.56) |
| 8QZI | Crystal structure of PptT-ACP from Mycobacterium tuberculosis | x-ray diffraction | A, B, C, D | COA, MN | 7 (best 0.81) |
| 8QZJ | Crystal structure of PptT-ADP from Mycobacterium tuberculosis | x-ray diffraction | A, B, C, D | A3P, MN | 7 (best 0.80) |
| O33336 | AlphaFold monomer V2.0 prediction for 4'-phosphopantetheinyl transferase pptt (O33336) | predicted | A | — | 1 (best 0.62) |
Ligands
- COA · Coenzyme A · in 6 records
- MG · Magnesium ion · in 6 records
- 0UD · N-[2,6-di(propan-2-yl)phenyl]-N'-(N-ethylcarbamimidoyl)urea · in 2 records
- 10I · N-(2,6-diethylphenyl)-N'-(N-propylcarbamimidoyl)urea · in 2 records
- MN · Manganese (II) ion · in 2 records
- 17I · N-(2,6-diethylphenyl)-N'-(N-methylcarbamimidoyl)urea · in 1 record
- A3P · Adenosine-3'-5'-diphosphate · in 1 record
Experiment against prediction
- 8QZJ chain C against the predicted model O33336: TM-score 0.99, RMSD 0.55 Å
- 8QZJ chain B against the predicted model O33336: TM-score 0.99, RMSD 0.63 Å
- 8QZI chain A against the predicted model O33336: TM-score 0.99, RMSD 0.69 Å
- 8QZJ chain A against the predicted model O33336: TM-score 0.99, RMSD 0.64 Å
- 4QVH chain A against the predicted model O33336: TM-score 0.38, RMSD 0.68 Å
- 4QVH chain A against the predicted model O33336: TM-score 0.38, RMSD 0.68 Å
- 8QZJ chain D against the predicted model O33336: TM-score 0.99, RMSD 0.77 Å
- 4QVH chain B against the predicted model O33336: TM-score 0.38, RMSD 0.73 Å
- 4QVH chain B against the predicted model O33336: TM-score 0.38, RMSD 0.73 Å
- 8QZH chain A against the predicted model O33336: TM-score 0.95, RMSD 0.99 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.