UniProt O25664
Bifunctional enzyme IspD/IspF (O25664)
Bifunctional enzyme IspD/IspF (UniProt O25664), EC 2.7.7.60, 4.6.1.12: 2 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 37 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O25664
- Protein
- Bifunctional enzyme IspD/IspF
- EC
- 2.7.7.60, 4.6.1.12
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 37 · 2 records with a druggable one
Structures
3 records of O25664 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8XHU | Crystal structure of Helicobacter pylori IspDF | x-ray diffraction | A, B, C | SO4, ZN, CL | 17 (best 0.84) |
| 8XKF | Crystal structure of Helicobacter pylori IspDF with substrate CTP | x-ray diffraction | A, B, C, D, E, F | CL, CTP, ZN, C5P, SO4, CDP | 20 (best 0.85) |
| O25664 | AlphaFold monomer V2.0 prediction for bifunctional enzyme ISPD/ISPF (O25664) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8XKF chain E against the predicted model O25664: TM-score 0.99, RMSD 0.57 Å
- 8XKF chain C against the predicted model O25664: TM-score 0.99, RMSD 0.65 Å
- 8XKF chain D against the predicted model O25664: TM-score 0.99, RMSD 0.67 Å
- 8XKF chain F against the predicted model O25664: TM-score 0.99, RMSD 0.67 Å
- 8XKF chain B against the predicted model O25664: TM-score 0.99, RMSD 0.69 Å
- 8XKF chain A against the predicted model O25664: TM-score 0.99, RMSD 0.69 Å
- 8XHU chain C against the predicted model O25664: TM-score 0.99, RMSD 0.75 Å
- 8XHU chain B against the predicted model O25664: TM-score 0.99, RMSD 0.78 Å
- 8XHU chain A against the predicted model O25664: TM-score 0.99, RMSD 0.84 Å
Elsewhere
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