UniProt O22287
Mannose-1-phosphate guanylyltransferase 1 (O22287)
Mannose-1-phosphate guanylyltransferase 1 (UniProt O22287), EC 2.7.7.13: 4 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O22287
- Protein
- Mannose-1-phosphate guanylyltransferase 1
- EC
- 2.7.7.13
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 15 · 2 records with a druggable one
Structures
5 records of O22287 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7X8J | Arabidopsis GDP-D-mannose pyrophosphorylase (VTC1) structure (unliganded) | x-ray diffraction | A, B | SO4 | 6 (best 0.57) |
| 7X8J | Arabidopsis GDP-D-mannose pyrophosphorylase (VTC1) structure (unliganded) | x-ray diffraction | A, B | SO4 | — |
| 7X8K | Arabidopsis GDP-D-mannose pyrophosphorylase (VTC1) structure (product-bound) | x-ray diffraction | A, B, C, D | GDD, SO4, PPV | 9 (best 0.68) |
| 7X8K | Arabidopsis GDP-D-mannose pyrophosphorylase (VTC1) structure (product- bound) | x-ray diffraction | A, B, C, D | GDD, SO4, PPV | — |
| O22287 | AlphaFold monomer V2.0 prediction for mannose-1-phosphate guanylyltransferase 1 (O22287) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7X8K chain C against the predicted model O22287: TM-score 0.98, RMSD 0.96 Å
- 7X8K chain C against the predicted model O22287: TM-score 0.98, RMSD 0.96 Å
- 7X8J chain A against the predicted model O22287: TM-score 0.98, RMSD 0.98 Å
- 7X8J chain A against the predicted model O22287: TM-score 0.98, RMSD 0.98 Å
- 7X8J chain B against the predicted model O22287: TM-score 0.98, RMSD 1.07 Å
- 7X8J chain B against the predicted model O22287: TM-score 0.98, RMSD 1.07 Å
- 7X8K chain A against the predicted model O22287: TM-score 0.97, RMSD 1.12 Å
- 7X8K chain A against the predicted model O22287: TM-score 0.97, RMSD 1.12 Å
- 7X8K chain D against the predicted model O22287: TM-score 0.97, RMSD 1.12 Å
- 7X8K chain D against the predicted model O22287: TM-score 0.97, RMSD 1.12 Å
Elsewhere
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