UniProt O18823
Acyloxyacyl hydrolase large subunit (O18823)
Acyloxyacyl hydrolase large subunit (UniProt O18823), EC 3.1.1.77: 4 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O18823
- Protein
- Acyloxyacyl hydrolase large subunit
- EC
- 3.1.1.77
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 21 · 2 records with a druggable one
Structures
5 records of O18823 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5W7A | Rabbit acyloxyacyl hydrolase (AOAH), proteolytically processed, S262A mutant, with LPS (low quality… | x-ray diffraction | A, B | NAG, CA, PO4, FTT | 7 (best 0.77) |
| 5W7A | Rabbit acyloxyacyl hydrolase (aoah), proteolytically processed, S262A mutant, with lps (low quality… | x-ray diffraction | A, B | NAG, CA, PO4, FTT | — |
| 5W7B | Rabbit acyloxyacyl hydrolase (AOAH), proteolytically processed, S262A mutant, with LPS | x-ray diffraction | A, C, B, D | NAG, FUC, PA1, GCS, KDO, FTT | 14 (best 0.78) |
| 5W7B | Rabbit acyloxyacyl hydrolase (aoah), proteolytically processed, S262A mutant, with lps | x-ray diffraction | A, C, B, D | NAG, FUC, PA1, GCS, KDO, FTT | — |
| O18823 | AlphaFold monomer V2.0 prediction for acyloxyacyl hydrolase (O18823) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 4 records
- FTT · 3-hydroxy-tetradecanoic acid · in 4 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- PO4 · Phosphate ion · in 4 records
- FUC · alpha-L-fucopyranose · in 2 records
- GCS · 2-amino-2-deoxy-beta-D-glucopyranose · in 2 records
- KDO · 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid · in 2 records
- MYR · Myristic acid · in 2 records
- PA1 · 2-amino-2-deoxy-alpha-D-glucopyranose · in 2 records
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 5W7A chain B against the predicted model O18823: TM-score 0.99, RMSD 0.91 Å
- 5W7A chain B against the predicted model O18823: TM-score 0.99, RMSD 0.91 Å
- 5W7B chain C against the predicted model O18823: TM-score 0.98, RMSD 1.46 Å
- 5W7B chain C against the predicted model O18823: TM-score 0.98, RMSD 1.46 Å
- 5W7B chain D against the predicted model O18823: TM-score 0.98, RMSD 1.48 Å
- 5W7B chain D against the predicted model O18823: TM-score 0.98, RMSD 1.48 Å
- 5W7B chain A against the predicted model O18823: TM-score 0.86, RMSD 1.72 Å
- 5W7B chain A against the predicted model O18823: TM-score 0.86, RMSD 1.72 Å
- 5W7A chain A against the predicted model O18823: TM-score 0.86, RMSD 1.35 Å
- 5W7A chain A against the predicted model O18823: TM-score 0.86, RMSD 1.35 Å
Elsewhere
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