UniProt O18473
Ecdysone receptor (O18473)
Ecdysone receptor (UniProt O18473): 8 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 50 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O18473
- Protein
- Ecdysone receptor
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 50 · 8 records with a druggable one
Structures
9 records of O18473 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1R1K | Crystal structure of the ligand-binding domains of the heterodimer EcR/USP bound to ponasterone A | x-ray diffraction | D | P1A | 5 (best 0.85) |
| 1R1K | Crystal structure of the ligand-binding domains of the heterodimer ECR/USP bound to ponasterone a | x-ray diffraction | D | P1A | 5 (best 0.85) |
| 1R20 | Crystal structure of the ligand-binding domains of the heterodimer EcR/USP bound to the synthetic… | x-ray diffraction | D | HWG | 6 (best 0.81) |
| 1R20 | Crystal structure of the ligand-binding domains of the heterodimer ECR/USP bound to the synthetic… | x-ray diffraction | D | HWG | 6 (best 0.81) |
| 2R40 | Crystal structure of 20E bound EcR/USP | x-ray diffraction | D | SO4, 20E | 6 (best 0.84) |
| 2R40 | Crystal structure of 20E bound ECR/USP | x-ray diffraction | D | SO4, 20E | 6 (best 0.84) |
| 4UMM | The Cryo-EM structure of the palindromic DNA-bound USP-EcR nuclear receptor reveals an asymmetric… | electron microscopy | E, G | P1A | 8 (best 0.84) |
| 4UMM | The cryo-EM structure of the palindromic DNA-bound usp-ecr nuclear receptor reveals an asymmetric… | electron microscopy | E, G | P1A | 8 (best 0.84) |
| O18473 | AlphaFold monomer V2.0 prediction for ecdysone receptor (O18473) | predicted | A | — | — |
Ligands
- P1A · 2,3,14,20,22-pentahydroxycholest-7-en-6-one · in 4 records
- 20E · (2beta,3beta,5beta,22R)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one · in 2 records
- HWG · N-(tert-butyl)-3,5-dimethyl-N'-[(5-methyl-2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]benzohydrazide · in 2 records
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 2R40 chain D against the predicted model O18473: TM-score 0.99, RMSD 0.70 Å
- 2R40 chain D against the predicted model O18473: TM-score 0.99, RMSD 0.70 Å
- 1R1K chain D against the predicted model O18473: TM-score 0.98, RMSD 0.80 Å
- 1R1K chain D against the predicted model O18473: TM-score 0.98, RMSD 0.80 Å
- 4UMM chain G against the predicted model O18473: TM-score 0.98, RMSD 0.80 Å
- 4UMM chain G against the predicted model O18473: TM-score 0.98, RMSD 0.80 Å
- 1R20 chain D against the predicted model O18473: TM-score 0.95, RMSD 1.43 Å
- 1R20 chain D against the predicted model O18473: TM-score 0.95, RMSD 1.43 Å
- 4UMM chain E against the predicted model O18473: TM-score 0.89, RMSD 1.99 Å
- 4UMM chain E against the predicted model O18473: TM-score 0.89, RMSD 1.99 Å
Elsewhere
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