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Ligand · P1A

P1A · 2,3,14,20,22-pentahydroxycholest-7-en-6-one

P1A, 2,3,14,20,22-pentahydroxycholest-7-en-6-one (C27 H44 O6, 464.6 g/mol), in the MolNFT structures on GenesisL1: bound in 10 records (5 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component
P1A
Formula
C27 H44 O6
Class
ligand
Structures
10
PDB entries
5

Binding sites

P1A in 10 structures; the first of them:

  • 1R1K · Crystal structure of the ligand-binding domains of the heterodimer EcR/USP bound to… · P1A D3000 · binds GLU309, GLN310, PRO311, ILE339, THR340, MET342, THR343, THR346 and 17 more
  • 1Z5X · hemipteran ecdysone receptor ligand-binding domain complexed with ponasterone A · P1A E5 · binds GLU199, HIS200, PRO201, ILE227, THR228, ILE230, THR231, THR234 and 17 more
  • 2NXX · Crystal Structure of the Ligand-Binding Domains of the T.castaneum (Coleoptera)… · P1A E5 · binds GLU330, HIS331, PRO332, ILE358, THR359, ILE361, THR362, THR365 and 18 more
  • 4OZT · crystal structure of the ligand binding domains of the Bovicola ovis ecdysone receptor… · P1A E601 · binds GLU303, GLN304, PRO305, ILE331, THR332, ILE334, THR335, THR338 and 17 more
  • 4UMM · The Cryo-EM structure of the palindromic DNA-bound USP-EcR nuclear receptor reveals an… · P1A G1530 · binds GLU309, GLN310, PRO311, ILE339, THR340, MET342, THR343, THR346 and 17 more
  • 1R1K · Crystal structure of the ligand-binding domains of the heterodimer ECR/USP bound to… · P1A D3000 · binds GLU309, GLN310, PRO311, ILE339, THR340, MET342, THR343, THR346 and 17 more
  • 1Z5X · Hemipteran ecdysone receptor ligand-binding domain complexed with ponasterone a · P1A E5 · binds GLU199, HIS200, PRO201, ILE227, THR228, ILE230, THR231, THR234 and 17 more
  • 2NXX · Crystal structure of the ligand-binding domains of the T.CASTANEUM (coleoptera)… · P1A E5 · binds GLU330, HIS331, PRO332, ILE358, THR359, ILE361, THR362, THR365 and 18 more
  • 4OZT · Crystal structure of the ligand binding domains of the bovicola ovis ecdysone receptor… · P1A E601 · binds GLU303, GLN304, PRO305, ILE331, THR332, ILE334, THR335, THR338 and 17 more
  • 4UMM · The cryo-EM structure of the palindromic DNA-bound usp-ecr nuclear receptor reveals an… · P1A G1530 · binds GLU309, GLN310, PRO311, ILE339, THR340, MET342, THR343, THR346 and 17 more

Residues it binds most

MET 16, LEU 16, THR 16, ILE 16, ARG 16, VAL 12, ASN 16, GLU 16, PHE 16, PRO 16 (residue and the binding sites it lines).

Found with

  • EPH · L-alpha-phosphatidyl-beta-oleoyl-gamma-palmitoyl-phosphatidylethanolamine
  • NEQ · N-ethylmaleimide
  • PO4 · Phosphate ion

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