UniProt O15552
Free fatty acid receptor 2 (O15552)
Free fatty acid receptor 2 (UniProt O15552): 4 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O15552
- Protein
- Free fatty acid receptor 2
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 19 · 4 records with a druggable one
Structures
5 records of O15552 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8J22 | Cryo-EM structure of FFAR2 complex bound with TUG-1375 | electron microscopy | C | 9UJ | 5 (best 0.79) |
| 8J23 | Cryo-EM structure of FFAR2 complex in apo state | electron microscopy | A | — | 5 (best 0.72) |
| 8J24 | Cryo-EM structure of FFAR2 complex bound with acetic acid | electron microscopy | D | — | 4 (best 0.75) |
| 9K1D | Cryo-EM structure of the butyrate bound FFA2-Gi complex | electron microscopy | R | BUA, CLR | 5 (best 0.74) |
| O15552 | AlphaFold monomer V2.0 prediction for free fatty acid receptor 2 (O15552) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8J24 chain D against the predicted model O15552: TM-score 0.99, RMSD 0.64 Å
- 8J23 chain A against the predicted model O15552: TM-score 0.97, RMSD 1.17 Å
- 9K1D chain R against the predicted model O15552: TM-score 0.96, RMSD 1.32 Å
- 8J22 chain C against the predicted model O15552: TM-score 0.91, RMSD 2.14 Å
Elsewhere
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