UniProt O15527
N-glycosylase/DNA lyase (O15527)
N-glycosylase/DNA lyase (UniProt O15527), EC 3.2.2.-, 4.2.99.18: 66 experimental structures on GenesisL1, 5 ligands bound, 32 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O15527
- Protein
- N-glycosylase/DNA lyase
- EC
- 3.2.2.-, 4.2.99.18
- Experimental structures
- 66
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 32 · 6 records with a druggable one
Structures
66 records of O15527 in the MolNFT archive: 66 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1EBM | Crystal structure of the human 8-oxoguanine glycosylase (HOGG1) bound to a substrate oligonucleotide | x-ray diffraction | A | — | — |
| 1EBM | Crystal structure of the human 8-oxoguanine glycosylase (HOGG1) bound to a substrate oligonucleotide | x-ray diffraction | A | — | — |
| 1FN7 | Coupling of damage recognition and catalysis by a human base-excision DNA repair protein | x-ray diffraction | A | — | — |
| 1FN7 | Coupling of damage recognition and catalysis by a human base-excision DNA repair protein | x-ray diffraction | A | — | — |
| 1HU0 | Crystal structure of an HOGG1-DNA borohydride trapped intermediate complex | x-ray diffraction | A | — | — |
| 1HU0 | Crystal structure of an HOGG1-DNA borohydride trapped intermediate complex | x-ray diffraction | A | — | — |
| 1KO9 | Native Structure of the Human 8-oxoguanine DNA Glycosylase hOGG1 | x-ray diffraction | A | — | — |
| 1KO9 | Native structure of the human 8-oxoguanine DNA glycosylase HOGG1 | x-ray diffraction | A | — | — |
| 1LWV | Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-aminoguanine | x-ray diffraction | A | — | — |
| 1LWV | Borohydride-trapped HOGG1 intermediate structure co- crystallized with 8-aminoguanine | x-ray diffraction | A | — | — |
| 1LWW | Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-bromoguanine | x-ray diffraction | A | — | — |
| 1LWW | Borohydride-trapped HOGG1 intermediate structure co- crystallized with 8-bromoguanine | x-ray diffraction | A | — | — |
| 1LWY | hOgg1 Borohydride-Trapped Intermediate without 8-oxoguanine | x-ray diffraction | A | — | — |
| 1LWY | HOGG1 borohydride-trapped intermediate without 8-oxoguanine | x-ray diffraction | A | — | — |
| 1M3H | Crystal Structure of Hogg1 D268E Mutant with Product Oligonucleotide | x-ray diffraction | A | — | — |
| 1M3H | Crystal structure of HOGG1 D268E mutant with product oligonucleotide | x-ray diffraction | A | — | — |
| 1M3Q | Crystal Structure of hogg1 D268E Mutant with Base-Excised DNA and 8-aminoguanine | x-ray diffraction | A | — | — |
| 1M3Q | Crystal structure of HOGG1 D268E mutant with base-excised DNA and 8- aminoguanine | x-ray diffraction | A | — | — |
| 1N39 | Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase | x-ray diffraction | A | — | — |
| 1N39 | Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase | x-ray diffraction | A | — | — |
| 1N3A | Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase | x-ray diffraction | A | — | — |
| 1N3A | Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase | x-ray diffraction | A | — | — |
| 1N3C | Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase | x-ray diffraction | A | — | — |
| 1N3C | Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase | x-ray diffraction | A | — | — |
| 1YQK | Human 8-oxoguanine glycosylase crosslinked with guanine containing DNA | x-ray diffraction | A | — | — |
| 1YQK | Human 8-oxoguanine glycosylase crosslinked with guanine containing DNA | x-ray diffraction | A | — | — |
| 1YQL | Catalytically inactive hOGG1 crosslinked with 7-deaza-8-azaguanine containing DNA | x-ray diffraction | A | — | — |
| 1YQL | Catalytically inactive HOGG1 crosslinked with 7-deaza-8-azaguanine containing DNA | x-ray diffraction | A | — | — |
| 1YQM | Catalytically inactive human 8-oxoguanine glycosylase crosslinked to 7-deazaguanine containing DNA | x-ray diffraction | A | — | — |
| 1YQM | Catalytically inactive human 8-oxoguanine glycosylase crosslinked to 7-deazaguanine containing DNA | x-ray diffraction | A | — | — |
| 1YQR | Catalytically inactive human 8-oxoguanine glycosylase crosslinked to oxoG containing DNA | x-ray diffraction | A | — | — |
| 1YQR | Catalytically inactive human 8-oxoguanine glycosylase crosslinked to oxog containing DNA | x-ray diffraction | A | — | — |
| 2I5W | Structure of hOGG1 crosslinked to DNA sampling a normal G adjacent to an oxoG | x-ray diffraction | A | — | — |
| 2I5W | Structure of HOGG1 crosslinked to DNA sampling a normal G adjacent to an oxog | x-ray diffraction | A | — | — |
| 2NOB | Structure of catalytically inactive H270A human 8-oxoguanine glycosylase crosslinked to… | x-ray diffraction | A | — | — |
| 2NOB | Structure of catalytically inactive H270A human 8-oxoguanine glycosylase crosslinked to… | x-ray diffraction | A | — | — |
| 2NOE | Structure of catalytically inactive G42A human 8-oxoguanine glycosylase complexed to 8-oxoguanine… | x-ray diffraction | A | — | — |
| 2NOE | Structure of catalytically inactive G42A human 8-oxoguanine glycosylase complexed to 8-oxoguanine… | x-ray diffraction | A | — | — |
| 2NOF | Structure of Q315F human 8-oxoguanine glycosylase proximal crosslink to 8-oxoguanine DNA | x-ray diffraction | A | — | — |
| 2NOF | Structure of Q315F human 8-oxoguanine glycosylase proximal crosslink to 8-oxoguanine DNA | x-ray diffraction | A | — | — |
| 2NOH | Structure of catalytically inactive Q315A human 8-oxoguanine glycosylase complexed to 8-oxoguanine… | x-ray diffraction | A | — | — |
| 2NOH | Structure of catalytically inactive Q315A human 8-oxoguanine glycosylase complexed to 8-oxoguanine… | x-ray diffraction | A | — | — |
| 2NOI | Structure of G42A human 8-oxoguanine glycosylase crosslinked to undamaged G-containing DNA | x-ray diffraction | A | — | — |
| 2NOI | Structure of G42A human 8-oxoguanine glycosylase crosslinked to undamaged G-containing DNA | x-ray diffraction | A | — | — |
| 2NOL | Structure of catalytically inactive human 8-oxoguanine glycosylase distal crosslink to oxoG DNA | x-ray diffraction | A | — | — |
| 2NOL | Structure of catalytically inactive human 8-oxoguanine glycosylase distal crosslink to oxog DNA | x-ray diffraction | A | — | — |
| 2NOZ | Structure of Q315F human 8-oxoguanine glycosylase distal crosslink to 8-oxoguanine DNA | x-ray diffraction | A | — | — |
| 2NOZ | Structure of Q315F human 8-oxoguanine glycosylase distal crosslink to 8-oxoguanine DNA | x-ray diffraction | A | — | — |
| 2XHI | Separation-of-function mutants unravel the dual reaction mode of human 8-oxoguanine DNA glycosylase | x-ray diffraction | A | — | — |
| 2XHI | Separation-of-function mutants unravel the dual reaction mode of human 8-oxoguanine DNA glycosylase | x-ray diffraction | A | — | — |
| 3IH7 | Crystal structure of catalytically active human 8-oxoguanine glycosylase distally crosslinked to… | x-ray diffraction | A | — | — |
| 3IH7 | Crystal structure of catalytically active human 8-oxoguanine glycosylase distally crosslinked to… | x-ray diffraction | A | — | — |
| 3KTU | Structure of human 8-oxoGuanine Glycosylase 1 bound to fluorninated oxoG-containing DNA | x-ray diffraction | A | — | — |
| 3KTU | Structure of human 8-oxoguanine glycosylase 1 bound to fluorninated oxog-containing DNA | x-ray diffraction | A | — | — |
| 5AN4 | Crystal structure of the human 8-oxoguanine glycosylase (OGG1) processed with the CrystalDirect… | x-ray diffraction | A | — | — |
| 5AN4 | Crystal structure of the human 8-oxoguanine glycosylase (OGG1) processed with the crystaldirect… | x-ray diffraction | A | — | — |
| 6W0M | Human 8-oxoguanine glycosylase crosslinked with oxog lesion containing DNA | x-ray diffraction | A | MG, S5Y | — |
| 6W0R | Human 8-oxoguanine glycosylase interrogating fully intrahelical undamaged DNA | x-ray diffraction | A | NA, NO3, S5Y | — |
| 6W13 | Human 8-oxoguanine glycosylase interrogating fully intrahelical oxoG lesion DNA | x-ray diffraction | A | MG, S5Y | 5 (best 0.67) |
| 6W13 | Human 8-oxoguanine glycosylase interrogating fully intrahelical oxog lesion DNA | x-ray diffraction | A | MG, S5Y | — |
6 records more on the page itself.
Ligands
Elsewhere
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