UniProt O15514
DNA-directed RNA polymerase II subunit RPB4 (O15514)
DNA-directed RNA polymerase II subunit RPB4 (UniProt O15514): 18 experimental structures and 1 predicted model on GenesisL1, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O15514
- Protein
- DNA-directed RNA polymerase II subunit RPB4
- Experimental structures
- 18
- Predicted models
- 1
- Pockets
- 1 · 0 records with a druggable one
Structures
19 records of O15514 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2C35 | Subunits Rpb4 and Rpb7 of human RNA polymerase II | x-ray diffraction | A, C, E, G | — | — |
| 2C35 | Subunits RPB4 and RPB7 of human RNA polymerase II | x-ray diffraction | A, C, E, G | — | — |
| 5IY6 | Human holo-PIC in the closed state | electron microscopy | D | — | — |
| 5IY6 | Human holo-pic in the closed state | electron microscopy | D | — | — |
| 5IY7 | Human holo-pic in the open state | electron microscopy | D | — | — |
| 5IY8 | Human holo-pic in the initial transcribing state | electron microscopy | D | — | — |
| 5IY9 | Human holo-PIC in the initial transcribing state (no IIS) | electron microscopy | D | — | — |
| 5IY9 | Human holo-pic in the initial transcribing state (no iis) | electron microscopy | D | — | — |
| 5IYA | Human core-PIC in the closed state | electron microscopy | D | — | — |
| 5IYA | Human core-pic in the closed state | electron microscopy | D | — | — |
| 5IYB | Human core-pic in the open state | electron microscopy | D | — | — |
| 5IYC | Human core-PIC in the initial transcribing state | electron microscopy | D | — | — |
| 5IYC | Human core-pic in the initial transcribing state | electron microscopy | D | — | — |
| 5IYD | Human core-PIC in the initial transcribing state (no IIS) | electron microscopy | D | — | — |
| 5IYD | Human core-pic in the initial transcribing state (no iis) | electron microscopy | D | — | — |
| 6DRD | RNA pol II(G) | electron microscopy | D | — | — |
| 6O9L | Human holo-pic in the closed state | electron microscopy | D | — | — |
| 6XRE | Structure of the P53/RNA polymerase II assembly | electron microscopy | D | — | — |
| O15514 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase II subunit RPB4 (O15514) | predicted | A | — | 1 (best 0.27) |
Experiment against prediction
- 2C35 chain E against the predicted model O15514: TM-score 0.95, RMSD 1.09 Å
- 2C35 chain E against the predicted model O15514: TM-score 0.95, RMSD 1.09 Å
- 2C35 chain A against the predicted model O15514: TM-score 0.92, RMSD 1.57 Å
- 2C35 chain A against the predicted model O15514: TM-score 0.92, RMSD 1.57 Å
- 5IYD chain D against the predicted model O15514: TM-score 0.92, RMSD 1.22 Å
- 5IYD chain D against the predicted model O15514: TM-score 0.92, RMSD 1.22 Å
- 5IY9 chain D against the predicted model O15514: TM-score 0.92, RMSD 1.22 Å
- 5IY9 chain D against the predicted model O15514: TM-score 0.92, RMSD 1.22 Å
- 5IY8 chain D against the predicted model O15514: TM-score 0.91, RMSD 1.69 Å
- 5IYC chain D against the predicted model O15514: TM-score 0.91, RMSD 1.69 Å
Elsewhere
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