UniProt O15496
Group 10 secretory phospholipase A2 (O15496)
Group 10 secretory phospholipase A2 (UniProt O15496), EC 3.1.1.4: 14 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 22 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O15496
- Protein
- Group 10 secretory phospholipase A2
- EC
- 3.1.1.4
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 22 · 7 records with a druggable one
Structures
15 records of O15496 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1LE6 | Carboxylic ester hydrolase, P 1 21 1 space group | x-ray diffraction | A, B, C | CA | 6 (best 0.63) |
| 1LE6 | Carboxylic ester hydrolase, P 1 21 1 space group | x-ray diffraction | A, B, C | — | — |
| 1LE7 | CARBOXYLIC ESTER HYDROLASE, C 2 2 21 space group | x-ray diffraction | A, B | CA | 3 (best 0.62) |
| 1LE7 | Carboxylic ester hydrolase, C 2 2 21 space group | x-ray diffraction | A, B | — | — |
| 4UY1 | Novel pyrazole series of group X Secretory Phospholipase A2 (sPLA2-X) inhibitors | x-ray diffraction | A, B | — | — |
| 4UY1 | Novel pyrazole series of group X secretory phospholipase A2 (SPLA2-X) inhibitors | x-ray diffraction | A, B | — | — |
| 5G3M | Discovery of a novel secreted phospholipase A2 (sPLA2) inhibitor. | x-ray diffraction | A, B | CA, 9JH | 2 (best 0.58) |
| 5G3M | Discovery of a novel secreted phospholipase A2 (SPLA2) inhibitor. | x-ray diffraction | A, B | — | — |
| 5OW8 | Indole-2 carboxamides as selective secreted phospholipase A2 type X (sPLA2-X) inhibitors | x-ray diffraction | A, B | CA, AYN, CL | 3 (best 0.58) |
| 5OW8 | Indole-2 carboxamides as selective secreted phospholipase A2 type X (SPLA2-X) inhibitors | x-ray diffraction | A, B | CA, AYN, CL | — |
| 5OWC | Indole-2 carboxamides as selective secreted phospholipase A2 type X (sPLA2-X) inhibitors | x-ray diffraction | A, B | CA, AYZ | 3 (best 0.57) |
| 5OWC | Indole-2 carboxamides as selective secreted phospholipase A2 type X (SPLA2-X) inhibitors | x-ray diffraction | A, B | CA, AYZ | — |
| 6G5J | Secreted phospholipase A2 type X in complex with ligand | x-ray diffraction | A, B | CA, EM8 | 3 (best 0.55) |
| 6G5J | Secreted phospholipase A2 type X in complex with ligand | x-ray diffraction | A, B | CA, EM8 | — |
| O15496 | AlphaFold monomer V2.0 prediction for group 10 secretory phospholipase A2 (O15496) | predicted | A | — | 2 (best 0.60) |
Ligands
- CA · Calcium ion · in 9 records
- AYN · 1-[3-(trifluoromethyl)phenyl]indole-2-carboxamide · in 2 records
- AYZ · 3-[3-[2-aminocarbonyl-6-(trifluoromethyloxy)indol-1-yl]phenyl]propanoic acid · in 2 records
- CL · Chloride ion · in 2 records
- EM8 · (3~{R})-3-[3-[2-aminocarbonyl-6-(trifluoromethyloxy) indol-1-yl]phenyl]butanoic acid · in 2 records
- 9JH · 4-benzylbenzamide · in 1 record
Experiment against prediction
- 5OWC chain A against the predicted model O15496: TM-score 0.99, RMSD 0.43 Å
- 5OWC chain A against the predicted model O15496: TM-score 0.99, RMSD 0.43 Å
- 6G5J chain A against the predicted model O15496: TM-score 0.99, RMSD 0.44 Å
- 6G5J chain A against the predicted model O15496: TM-score 0.99, RMSD 0.44 Å
- 6G5J chain B against the predicted model O15496: TM-score 0.99, RMSD 0.45 Å
- 6G5J chain B against the predicted model O15496: TM-score 0.99, RMSD 0.45 Å
- 4UY1 chain B against the predicted model O15496: TM-score 0.99, RMSD 0.46 Å
- 4UY1 chain B against the predicted model O15496: TM-score 0.99, RMSD 0.46 Å
- 5OW8 chain A against the predicted model O15496: TM-score 0.99, RMSD 0.49 Å
- 5OW8 chain A against the predicted model O15496: TM-score 0.99, RMSD 0.49 Å
Elsewhere
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