UniProt O14672
Disintegrin and metalloproteinase domain-containing protein 10 (O14672)
Disintegrin and metalloproteinase domain-containing protein 10 (UniProt O14672), EC 3.4.24.81: 5 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 31 pockets. Binding sites, druggability and experiment…
- UniProt
- O14672
- Protein
- Disintegrin and metalloproteinase domain-containing protein 10
- EC
- 3.4.24.81
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 31 · 3 records with a druggable one
Structures
6 records of O14672 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6BDZ | ADAM10 Extracellular Domain Bound by the 11G2 Fab | x-ray diffraction | A | NAG, MAN, CA, ZN | 3 (best 0.75) |
| 6BDZ | ADAM10 extracellular domain bound by the 11G2 Fab | x-ray diffraction | A | NAG, CA, ZN | — |
| 6BE6 | ADAM10 Extracellular Domain | x-ray diffraction | A, B, C, D | NAG, MAN, ZN, CA, SO4 | 20 (best 0.82) |
| 6BE6 | ADAM10 extracellular domain | x-ray diffraction | A, B, C, D | NAG, MAN, ZN, CA, SO4 | — |
| 8ESV | Structure of human ADAM10-Tspan15 complex bound to 11G2 vFab | electron microscopy | A | NAG, MAN, CA, ZN, BAT | 8 (best 0.62) |
| O14672 | AlphaFold monomer V2.0 prediction for disintegrin and metalloproteinase domain-containing protein… | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 5 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- ZN · Zinc ion · in 5 records
- MAN · alpha-D-mannopyranose · in 4 records
- SO4 · Sulfate ion · in 2 records
- BAT · 4-(N-hydroxyamino)-2R-isobutyl-2S-(2-thienylthiomethyl)succinyl-L-phenylalanine-N-methylamide · in 1 record
Experiment against prediction
- 6BE6 chain C against the predicted model O14672: TM-score 0.59, RMSD 3.64 Å
- 6BE6 chain C against the predicted model O14672: TM-score 0.59, RMSD 3.64 Å
- 6BDZ chain A against the predicted model O14672: TM-score 0.59, RMSD 3.17 Å
- 6BDZ chain A against the predicted model O14672: TM-score 0.59, RMSD 3.17 Å
- 6BE6 chain B against the predicted model O14672: TM-score 0.59, RMSD 3.44 Å
- 6BE6 chain B against the predicted model O14672: TM-score 0.59, RMSD 3.44 Å
- 6BE6 chain A against the predicted model O14672: TM-score 0.59, RMSD 3.30 Å
- 6BE6 chain A against the predicted model O14672: TM-score 0.59, RMSD 3.30 Å
- 6BE6 chain D against the predicted model O14672: TM-score 0.58, RMSD 3.54 Å
- 6BE6 chain D against the predicted model O14672: TM-score 0.58, RMSD 3.54 Å
Elsewhere
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