UniProt O14649
Potassium channel subfamily K member 3 (O14649)
Potassium channel subfamily K member 3 (UniProt O14649): 7 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 36 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O14649
- Protein
- Potassium channel subfamily K member 3
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 36 · 5 records with a druggable one
Structures
8 records of O14649 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6RV2 | Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed… | x-ray diffraction | A, B, C, D | K, Y01, PC1 | 10 (best 0.85) |
| 6RV2 | Crystal structure of the human two pore domain potassium ion channel task-1 (K2P3.1) in a closed… | x-ray diffraction | A, B, C, D | K, Y01, PC1 | — |
| 6RV3 | Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed… | x-ray diffraction | A, B, C, D | K, Y01, PC1, KKQ | 9 (best 0.85) |
| 6RV3 | Crystal structure of the human two pore domain potassium ion channel task-1 (K2P3.1) in a closed… | x-ray diffraction | A, B, C, D | K, Y01, PC1, KKQ | — |
| 6RV4 | Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed… | x-ray diffraction | A, B, C, D | K, Y01, KKZ, PC1 | 9 (best 0.85) |
| 6RV4 | Crystal structure of the human two pore domain potassium ion channel task-1 (K2P3.1) in a closed… | x-ray diffraction | A, B, C, D | K, Y01, KKZ, PC1 | — |
| 9G9X | Structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) | electron microscopy | A, B | Y01, K | 5 (best 0.86) |
| O14649 | AlphaFold monomer V2.0 prediction for potassium channel subfamily K member 3 (O14649) | predicted | A | — | 3 (best 0.63) |
Ligands
- K · Potassium ion · in 7 records
- Y01 · Cholesterol hemisuccinate · in 7 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 6 records
- KKQ · [4-[[2-(4-bromophenyl)imidazo[1,2-a]pyridin-3-yl]methyl]piperazin-1-yl]-(2-fluorophenyl)methanone · in 2 records
- KKZ · [4-[[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]methyl]piperazin-1-yl]-[6-(trifluoromethyloxy) pyridin-2-yl]methanone · in 2 records
Experiment against prediction
- 6RV2 chain B against the predicted model O14649: TM-score 1.00, RMSD 0.39 Å
- 6RV2 chain B against the predicted model O14649: TM-score 1.00, RMSD 0.39 Å
- 6RV2 chain A against the predicted model O14649: TM-score 1.00, RMSD 0.40 Å
- 6RV2 chain A against the predicted model O14649: TM-score 1.00, RMSD 0.40 Å
- 6RV2 chain D against the predicted model O14649: TM-score 1.00, RMSD 0.41 Å
- 6RV2 chain D against the predicted model O14649: TM-score 1.00, RMSD 0.41 Å
- 6RV4 chain B against the predicted model O14649: TM-score 0.99, RMSD 0.43 Å
- 6RV4 chain B against the predicted model O14649: TM-score 0.99, RMSD 0.43 Å
- 6RV3 chain B against the predicted model O14649: TM-score 0.99, RMSD 0.44 Å
- 6RV3 chain B against the predicted model O14649: TM-score 0.99, RMSD 0.44 Å
Elsewhere
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