UniProt O14558
Heat shock protein beta-6 (O14558)
Heat shock protein beta-6 (UniProt O14558): 14 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O14558
- Protein
- Heat shock protein beta-6
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 10 · 3 records with a druggable one
Structures
15 records of O14558 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4JUS | Crystal structure of a fragment of Human HSPB6 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4JUS | Crystal structure of a fragment of human HSPB6 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4JUT | Crystal structure of a mutant fragment of Human HSPB6 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4JUT | Crystal structure of a mutant fragment of human HSPB6 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5LTW | Complex of human 14-3-3 sigma CLU1 mutant with phosphorylated heat shock protein B6 | x-ray diffraction | C, D, G, H, K, L | NI | — |
| 5LTW | Complex of human 14-3-3 sigma CLU1 mutant with phosphorylated heat shock protein B6 | x-ray diffraction | C, D, G, H, K, L | NI | — |
| 5LU1 | Human 14-3-3 sigma CLU3 mutant complexed with short HSPB6 phosphopeptide | x-ray diffraction | C, D, G, H | — | 4 (best 0.64) |
| 5LU1 | Human 14-3-3 sigma CLU3 mutant complexed with short HSPB6 phosphopeptide | x-ray diffraction | C, D, G, H | — | — |
| 5LU2 | Human 14-3-3 sigma complexed with long HSPB6 phosphopeptide | x-ray diffraction | C, D | — | 2 (best 0.54) |
| 5LU2 | Human 14-3-3 sigma complexed with long HSPB6 phosphopeptide | x-ray diffraction | C, D | — | — |
| 5LUM | Alpha-crystallin domain of human HSPB6 patched with its N-terminal peptide | x-ray diffraction | F, A, G, B, H, C, I, D, J, E | SO4 | 4 (best 0.62) |
| 5LUM | Alpha-crystallin domain of human HSPB6 patched with its N-terminal peptide | x-ray diffraction | F, A, G, B, H, C, I, D, J, E | SO4 | — |
| 5OK9 | CH1 chimera of human 14-3-3 sigma with the HSPB6 phosphopeptide in a conformation with swapped… | x-ray diffraction | A, B, E, F | — | — |
| 5OKF | CH1 chimera of human 14-3-3 sigma with the HSPB6 phosphopeptide in a conformation with self-bound… | x-ray diffraction | A, B, C, D | CD | — |
| O14558 | AlphaFold monomer V2.0 prediction for heat shock protein beta-6 (O14558) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5LUM chain E against the predicted model O14558: TM-score 0.97, RMSD 0.62 Å
- 5LUM chain D against the predicted model O14558: TM-score 0.97, RMSD 0.65 Å
- 5OKF chain A against the predicted model P31947: TM-score 0.95, RMSD 0.91 Å
- 5LUM chain A against the predicted model O14558: TM-score 0.95, RMSD 0.79 Å
- 5LUM chain A against the predicted model O14558: TM-score 0.95, RMSD 0.79 Å
- 5OKF chain B against the predicted model P31947: TM-score 0.95, RMSD 0.88 Å
- 5OKF chain C against the predicted model P31947: TM-score 0.94, RMSD 0.95 Å
- 5LTW chain G against the predicted model O14558: TM-score 0.94, RMSD 1.13 Å
- 5LTW chain G against the predicted model O14558: TM-score 0.94, RMSD 1.13 Å
- 5OKF chain D against the predicted model P31947: TM-score 0.94, RMSD 0.99 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.