UniProt O08760
N-glycosylase/DNA lyase (O08760)
N-glycosylase/DNA lyase (UniProt O08760), EC 3.2.2.-, 4.2.99.18: 8 experimental structures on GenesisL1, 7 ligands bound, 35 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O08760
- Protein
- N-glycosylase/DNA lyase
- EC
- 3.2.2.-, 4.2.99.18
- Experimental structures
- 8
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 35 · 3 records with a druggable one
Structures
8 records of O08760 in the MolNFT archive: 8 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G3X | Native structure of the mouse 8-oxoguanine DNA glycosylase MOGG1 | x-ray diffraction | A, B, C | NI | — |
| 6G3Y | Structure of the mouse 8-oxoguanine DNA glycosylase MOGG1 in complex with ligand TH5675 | x-ray diffraction | A, B, C | ELB, NI | — |
| 6G40 | Structure of the mouse 8-oxoguanine DNA glycosylase MOGG1 in complex with ligand TH9525 | x-ray diffraction | A, B, C | ELK, NI | — |
| 7AYZ | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with activator TH10785 | x-ray diffraction | AAA, BBB, CCC | SEQ, NI | 12 (best 0.82) |
| 7AZ0 | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with TH12161 | x-ray diffraction | AAA, BBB, CCC | SDW, NI | 10 (best 0.80) |
| 7PZ1 | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH8535 | x-ray diffraction | AAA, BBB, CCC | 8HA, NI | — |
| 8CEY | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH11233 | x-ray diffraction | A, B, C | UEF, NI | 13 (best 0.72) |
| O08760 | AlphaFold monomer V2.0 prediction for N-GLYCOSYLASE/DNA lyase (O08760) | — | — | — |
Ligands
- NI · Nickel (II) ion · in 7 records
- 8HA · 4-(4-bromanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(3-methoxy-4-methyl-phenyl)piperidine-1-carboxamide · in 1 record
- ELB · 4-(4-azanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(4-iodophenyl)piperidine-1-carboxamide · in 1 record
- ELK · ~{N}-(3-methoxy-4-methyl-phenyl)-4-(4-methoxy-2-oxidanylidene-3~{H}-benzimidazol-1-yl)piperidine-1-carboxamide · in 1 record
- SDW · 2-cyclopropyl-~{N}-(4-iodophenyl)quinazolin-4-amine · in 1 record
- SEQ · ~{N}-cyclohexyl-2-cyclopropyl-quinazolin-4-amine · in 1 record
- UEF · ~{N}-(3,3-dimethylcyclobutyl)imidazo[5,1-b][1,3]thiazole-3-carboxamide · in 1 record
Elsewhere
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