UniProt O00625
Pirin (O00625)
Pirin (UniProt O00625): 24 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O00625
- Protein
- Pirin
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 1 · 0 records with a druggable one
Structures
25 records of O00625 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1J1L | Crystal structure of human Pirin: a Bcl-3 and Nuclear factor I interacting protein and a cupin… | x-ray diffraction | A | — | — |
| 1J1L | Crystal structure of human pirin: a BCL-3 and nuclear factor I interacting protein and a cupin… | x-ray diffraction | A | — | — |
| 3ACL | Crystal Structure of Human Pirin in complex with Triphenyl Compound | x-ray diffraction | A | — | — |
| 3ACL | Crystal structure of human pirin in complex with triphenyl compound | x-ray diffraction | A | — | — |
| 4ERO | Study on structure and function relationships in human Pirin with Cobalt ion | x-ray diffraction | A | — | — |
| 4ERO | Study on structure and function relationships in human pirin with cobalt ion | x-ray diffraction | A | — | — |
| 4EWA | Study on structure and function relationships in human Pirin with Fe ion | x-ray diffraction | A | — | — |
| 4EWA | Study on structure and function relationships in human pirin with fe ion | x-ray diffraction | A | — | — |
| 4EWD | Study on structure and function relationships in human Pirin with Mn ion | x-ray diffraction | A | — | — |
| 4EWD | Study on structure and function relationships in human pirin with mn ion | x-ray diffraction | A | — | — |
| 4EWE | Study on structure and function relationships in human Pirin with Manganese ion | x-ray diffraction | A | — | — |
| 4EWE | Study on structure and function relationships in human pirin with manganese ion | x-ray diffraction | A | — | — |
| 4GUL | Study on structure and function relationships in human ferric Pirin | x-ray diffraction | A | — | — |
| 4GUL | Study on structure and function relationships in human ferric pirin | x-ray diffraction | A | — | — |
| 4HLT | Crystal structure of ferric E32V Pirin | x-ray diffraction | A | — | — |
| 4HLT | Crystal structure of ferric E32V pirin | x-ray diffraction | A | — | — |
| 5JCT | Crystal Structure of Human Pirin in complex with a Chemical Probe pyrrolidine 24 | x-ray diffraction | A | FE, 6JQ | — |
| 5JCT | Crystal structure of human pirin in complex with a chemical probe pyrrolidine 24 | x-ray diffraction | A | — | — |
| 6H1H | Crystal structure of human pirin in complex with compound 7 (PLX4720) | x-ray diffraction | A | FE, FJE | — |
| 6H1I | Crystal structure of human Pirin in complex with bisamide compound 2 | x-ray diffraction | A | FE, FJH | — |
| 6H1I | Crystal structure of human pirin in complex with bisamide compound 2 | x-ray diffraction | A | FE, FJH | — |
| 6N0J | The complex of CCG-222740 bound to pirin | x-ray diffraction | A | FE, K8S | — |
| 6N0J | The complex of ccg-222740 bound to pirin | x-ray diffraction | A | FE, K8S | — |
| 6N0K | The complex of ccg-257081 bound to pirin | x-ray diffraction | A | FE, K8M | — |
| O00625 | AlphaFold monomer V2.0 prediction for pirin (O00625) | predicted | A | — | 1 (best 0.48) |
Ligands
- FE · Fe (III) ion · in 7 records
- FJH · ~{N}-[5-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonylamino)-2-methyl-phenyl]-2-methyl-quinoline-6-carboxamide · in 2 records
- K8S · (3S)-N-(4-chlorophenyl)-5,5-difluoro-1-[3-(furan-2-yl) benzene-1-carbonyl]piperidine-3-carboxamide · in 2 records
- 6JQ · N-{5-[(2,3-dihydro-1,4-benzodioxine-6-carbonyl)amino]-2-methylphenyl}-2-[3-(pyrrolidin-1-yl)propyl]quinoline-6-carboxamide · in 1 record
- FJE · [3-azanyl-2,6-bis(fluoranyl)phenyl]-(5-chloranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)methanone · in 1 record
- K8M · (3R)-N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(pyridin-4-yl)benzene-1-carbonyl]piperidine-3-carboxamide · in 1 record
Experiment against prediction
- 6H1I chain A against the predicted model O00625: TM-score 0.99, RMSD 0.67 Å
- 6H1I chain A against the predicted model O00625: TM-score 0.99, RMSD 0.67 Å
- 4GUL chain A against the predicted model O00625: TM-score 0.99, RMSD 0.69 Å
- 4GUL chain A against the predicted model O00625: TM-score 0.99, RMSD 0.69 Å
- 5JCT chain A against the predicted model O00625: TM-score 0.99, RMSD 0.70 Å
- 5JCT chain A against the predicted model O00625: TM-score 0.99, RMSD 0.70 Å
- 4ERO chain A against the predicted model O00625: TM-score 0.99, RMSD 0.70 Å
- 4ERO chain A against the predicted model O00625: TM-score 0.99, RMSD 0.70 Å
- 4EWE chain A against the predicted model O00625: TM-score 0.99, RMSD 0.72 Å
- 4EWE chain A against the predicted model O00625: TM-score 0.99, RMSD 0.72 Å
Elsewhere
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