UniProt O00506
Serine/threonine-protein kinase 25 (O00506)
Serine/threonine-protein kinase 25 (UniProt O00506), EC 2.7.11.1: 8 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- O00506
- Protein
- Serine/threonine-protein kinase 25
- EC
- 2.7.11.1
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 8 · 5 records with a druggable one
Structures
9 records of O00506 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2XIK | Structure of Human YSK1 (Yeast Sps1-Ste20-related Kinase 1) | x-ray diffraction | A | J60 | 1 (best 0.67) |
| 2XIK | Structure of human YSK1 (yeast SPS1-STE20-related kinase 1) | x-ray diffraction | A | — | — |
| 3W8H | Crystal structure of CCM3 in complex with the C-terminal regulatory domain of STK25 | x-ray diffraction | B | SO4 | — |
| 3W8H | Crystal structure of CCM3 in complex with the C-terminal regulatory domain of STK25 | x-ray diffraction | B | — | — |
| 4NZW | Crystal Structure of STK25-MO25 Complex | x-ray diffraction | B | J60 | 3 (best 0.69) |
| 4NZW | Crystal structure of STK25-MO25 complex | x-ray diffraction | B | — | — |
| 7Z4V | Structure of Serine-Threonine kinase STK25 in complex with compound | x-ray diffraction | A | IB5 | 1 (best 0.64) |
| 7Z4V | Structure of serine-threonine kinase STK25 in complex with compound | x-ray diffraction | A | IB5 | 1 (best 0.64) |
| O00506 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase 25 (O00506) | predicted | A | — | 2 (best 0.77) |
Ligands
Experiment against prediction
- 4NZW chain B against the predicted model O00506: TM-score 0.95, RMSD 1.70 Å
- 4NZW chain B against the predicted model O00506: TM-score 0.95, RMSD 1.70 Å
- 2XIK chain A against the predicted model O00506: TM-score 0.94, RMSD 1.39 Å
- 2XIK chain A against the predicted model O00506: TM-score 0.94, RMSD 1.39 Å
- 7Z4V chain A against the predicted model O00506: TM-score 0.94, RMSD 1.43 Å
- 7Z4V chain A against the predicted model O00506: TM-score 0.94, RMSD 1.43 Å
- 3W8H chain B against the predicted model O00506: TM-score 0.86, RMSD 1.31 Å
- 3W8H chain B against the predicted model O00506: TM-score 0.86, RMSD 1.31 Å
Elsewhere
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