UniProt O00443
Phosphatidylinositol 4-phosphate 3-kinase C2 domain- containing subunit alpha (O00443)
Phosphatidylinositol 4-phosphate 3-kinase C2 domain- containing subunit alpha (UniProt O00443), EC 2.7.1.137, 2.7.1.154: 14 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 30 pockets. Binding sites…
- UniProt
- O00443
- Protein
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain- containing subunit alpha
- EC
- 2.7.1.137, 2.7.1.154
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 30 · 5 records with a druggable one
Structures
15 records of O00443 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2IWL | Structure of the PX Domain of Phosphoinositide 3-Kinase-C2alpha | x-ray diffraction | X | SO4 | — |
| 2IWL | Structure of the px domain of phosphoinositide 3-kinase-C2ALPHA | x-ray diffraction | X | SO4 | — |
| 2REA | Crystal structures of C2ALPHA-PI3 kinase PX-domain domain indicate conformational change associated… | x-ray diffraction | A | — | — |
| 2REA | Crystal structures of C2ALPHA-PI3 kinase px-domain domain indicate conformational change associated… | x-ray diffraction | A | — | — |
| 2RED | Crystal structures of C2ALPHA-PI3 kinase PX-domain domain indicate conformational change associated… | x-ray diffraction | A | — | 1 (best 0.36) |
| 2RED | Crystal structures of C2ALPHA-PI3 kinase px-domain domain indicate conformational change associated… | x-ray diffraction | A | — | 1 (best 0.36) |
| 6BTY | Crystal structure of the PI3KC2alpha C2 domain in space group P41212 | x-ray diffraction | A, B | O4B | 2 (best 0.54) |
| 6BTY | Crystal structure of the PI3KC2ALPHA C2 domain in space group P41212 | x-ray diffraction | A, B | O4B | 2 (best 0.54) |
| 6BTZ | Crystal structure of the PI3KC2alpha C2 domain in space group C121 | x-ray diffraction | A, B, C, D | SO4, O4B | 1 (best 0.40) |
| 6BTZ | Crystal structure of the PI3KC2ALPHA C2 domain in space group C121 | x-ray diffraction | A, B, C, D | SO4, O4B | 1 (best 0.40) |
| 6BU0 | Crystal structure of the PI3KC2alpha C2 domain in complex with IP6 | x-ray diffraction | A, B, C | IHP, O4B | 1 (best 0.58) |
| 6BU0 | Crystal structure of the PI3KC2ALPHA C2 domain in complex with IP6 | x-ray diffraction | A, B, C | IHP, O4B | 1 (best 0.58) |
| 6BUB | Crystal structure of the PI3KC2alpha PX domain in space group P432 | x-ray diffraction | A | SO4 | — |
| 6BUB | Crystal structure of the PI3KC2ALPHA px domain in space group P432 | x-ray diffraction | A | SO4 | — |
| O00443 | AlphaFold monomer V2.0 prediction for phosphatidylinositol 4-phosphate 3-kinase C2… | predicted | A | — | 20 (best 0.88) |
Ligands
Experiment against prediction
- 6BTZ chain A against the predicted model O00443: TM-score 0.99, RMSD 0.52 Å
- 6BTZ chain A against the predicted model O00443: TM-score 0.99, RMSD 0.52 Å
- 6BTY chain A against the predicted model O00443: TM-score 0.98, RMSD 0.52 Å
- 6BTY chain A against the predicted model O00443: TM-score 0.98, RMSD 0.52 Å
- 6BTZ chain D against the predicted model O00443: TM-score 0.98, RMSD 0.62 Å
- 6BTZ chain B against the predicted model O00443: TM-score 0.98, RMSD 0.64 Å
- 6BTY chain B against the predicted model O00443: TM-score 0.97, RMSD 0.83 Å
- 6BTY chain B against the predicted model O00443: TM-score 0.97, RMSD 0.83 Å
- 6BU0 chain A against the predicted model O00443: TM-score 0.97, RMSD 0.92 Å
- 6BU0 chain A against the predicted model O00443: TM-score 0.97, RMSD 0.92 Å
Elsewhere
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