UniProt O00217
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (O00217)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (UniProt O00217), EC 1.6.5.3, 1.6.99.3: 6 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 15 pockets. Binding sites, druggability…
- UniProt
- O00217
- Protein
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
- EC
- 1.6.5.3, 1.6.99.3
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 15 · 3 records with a druggable one
Structures
7 records of O00217 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5XTB | Cryo-EM structure of human respiratory complex I matrix arm | electron microscopy | B | SF4 | 8 (best 0.83) |
| 5XTB | Cryo-EM structure of human respiratory complex I matrix arm | electron microscopy | B | SF4 | — |
| 5XTD | Cryo-EM structure of human respiratory complex I | electron microscopy | B | SF4, PLX | 4 (best 0.83) |
| 5XTD | Cryo-EM structure of human respiratory complex I | electron microscopy | B | SF4, PLX | — |
| 5XTH | Cryo-EM structure of human respiratory supercomplex I1III2IV1 | electron microscopy | B | SF4, PLX | 2 (best 0.84) |
| 5XTI | Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 | electron microscopy | B, BB | SF4, PLX | — |
| O00217 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] iron-sulfur protein 8… | predicted | A | — | 1 (best 0.48) |
Ligands
Experiment against prediction
- 5XTI chain BB against the predicted model O00217: TM-score 0.96, RMSD 0.98 Å
- 5XTH chain B against the predicted model O00217: TM-score 0.96, RMSD 0.98 Å
- 5XTI chain B against the predicted model O00217: TM-score 0.96, RMSD 0.98 Å
- 5XTD chain B against the predicted model O00217: TM-score 0.96, RMSD 0.98 Å
- 5XTD chain B against the predicted model O00217: TM-score 0.96, RMSD 0.98 Å
- 5XTB chain B against the predicted model O00217: TM-score 0.96, RMSD 0.98 Å
- 5XTB chain B against the predicted model O00217: TM-score 0.96, RMSD 0.98 Å
Elsewhere
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