UniProt M1GRN3
Isoleucine 2-epimerase (M1GRN3)
Isoleucine 2-epimerase (UniProt M1GRN3), EC 5.1.1.21: 12 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 58 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- M1GRN3
- Protein
- Isoleucine 2-epimerase
- EC
- 5.1.1.21
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 58 · 5 records with a druggable one
Structures
13 records of M1GRN3 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4YSN | Structure of aminoacid racemase in complex with PLP | x-ray diffraction | A, B, C, D | — | — |
| 4YSN | Structure of aminoacid racemase in complex with plp | x-ray diffraction | A, B, C, D | — | — |
| 4YSV | Structure of aminoacid racemase in apo-form | x-ray diffraction | A | — | — |
| 4YSV | Structure of aminoacid racemase in apo-form | x-ray diffraction | A | — | — |
| 5LL2 | Structure of Isoleucine 2-epimerase from Lactobacillus buchneri (apo form) | x-ray diffraction | A, B, C, D | — | 12 (best 0.82) |
| 5LL2 | Structure of isoleucine 2-epimerase from lactobacillus buchneri (apo form) | x-ray diffraction | A, B, C, D | — | — |
| 5LL3 | Structure of the Isoleucine 2-epimerase from Lactobacillus buchneri (PLP complex form) | x-ray diffraction | A, B, C, D | PLP | 12 (best 0.83) |
| 5LL3 | Structure of the isoleucine 2-epimerase from lactobacillus buchneri (plp complex form) | x-ray diffraction | A, B, C, D | PLP | — |
| 5WYA | Structure of amino acid racemase, 2.65 A | x-ray diffraction | A, B, C, D | 7VO | 12 (best 0.85) |
| 5WYA | Structure of amino acid racemase, 2.65 a | x-ray diffraction | A, B, C, D | — | — |
| 5WYF | Structure of amino acid racemase, 2.12 A | x-ray diffraction | A, B, C, D | ILP, CD | 18 (best 0.84) |
| 5WYF | Structure of amino acid racemase, 2.12 a | x-ray diffraction | A, B, C, D | CD | — |
| M1GRN3 | AlphaFold monomer V2.0 prediction for isoleucine 2-epimerase (M1GRN3) | predicted | A | — | 4 (best 0.64) |
Ligands
Experiment against prediction
- 5WYA chain A against the predicted model M1GRN3: TM-score 1.00, RMSD 0.43 Å
- 5WYA chain B against the predicted model M1GRN3: TM-score 1.00, RMSD 0.48 Å
- 5WYF chain B against the predicted model M1GRN3: TM-score 1.00, RMSD 0.49 Å
- 5WYA chain A against the predicted model M1GRN3: TM-score 1.00, RMSD 0.69 Å
- 5WYF chain A against the predicted model M1GRN3: TM-score 1.00, RMSD 0.56 Å
- 5WYA chain B against the predicted model M1GRN3: TM-score 0.99, RMSD 0.73 Å
- 5LL3 chain A against the predicted model M1GRN3: TM-score 0.99, RMSD 0.58 Å
- 5LL3 chain A against the predicted model M1GRN3: TM-score 0.99, RMSD 0.58 Å
- 5WYF chain B against the predicted model M1GRN3: TM-score 0.99, RMSD 0.49 Å
- 5WYF chain A against the predicted model M1GRN3: TM-score 0.99, RMSD 0.56 Å
Elsewhere
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