UniProt J7RUA5
CRISPR-associated endonuclease Cas9 (J7RUA5)
CRISPR-associated endonuclease Cas9 (UniProt J7RUA5), EC 3.1.-.-: 13 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 113 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- J7RUA5
- Protein
- CRISPR-associated endonuclease Cas9
- EC
- 3.1.-.-
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 113 · 6 records with a druggable one
Structures
14 records of J7RUA5 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5AXW | Crystal structure of staphylococcus aureus CAS9 in complex with sgrna and target DNA (ttgggt pam) | x-ray diffraction | A | — | — |
| 5CZZ | Crystal structure of staphylococcus aureus CAS9 in complex with sgrna and target DNA (ttgaat pam) | x-ray diffraction | A | — | — |
| 7EL1 | Structure of a protein from bacteria | x-ray diffraction | A | — | 20 (best 0.84) |
| 7EL1 | Structure of a protein from bacteria | x-ray diffraction | A | — | — |
| 7ENH | Crystal structure of cas and anti-cas protein complex | x-ray diffraction | A | NI | — |
| 7ENH | Crystal structure of CAS and anti-CAS protein complex | x-ray diffraction | A | NI | — |
| 7ENI | Crystal structure of CAS and anti-CAS protein complex | x-ray diffraction | A | PO4 | — |
| 7ENR | Crystal structure of cas and anti-cas protein complex | x-ray diffraction | A | — | 16 (best 0.84) |
| 7ENR | Crystal structure of CAS and anti-CAS protein complex | x-ray diffraction | A | — | — |
| 7VW3 | Cryo-EM structure of SaCas9-sgRNA-DNA ternary complex | electron microscopy | A | MG | 20 (best 0.85) |
| 8JFT | Cryo-EM structure of SaCas9-AcrIIA15 CTD-sgRNA complex | electron microscopy | A | — | 20 (best 0.86) |
| 8JG9 | Cryo-EM structure of the SaCas9-sgRNA-AcrIIA15-promoter DNA dimer | electron microscopy | A, D | — | 20 (best 0.87) |
| 8Y0D | Crystal structure of SauCas9 in complex with sgRNA and 20nt ssDNA target | x-ray diffraction | A | — | 17 (best 0.86) |
| J7RUA5 | AlphaFold monomer V2.0 prediction for CRISPR-associated endonuclease CAS9 (J7RUA5) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5AXW chain A against the predicted model J7RUA5: TM-score 0.99, RMSD 0.87 Å
- 5CZZ chain A against the predicted model J7RUA5: TM-score 0.99, RMSD 0.89 Å
- 7ENH chain A against the predicted model J7RUA5: TM-score 0.92, RMSD 1.67 Å
- 7ENH chain A against the predicted model J7RUA5: TM-score 0.92, RMSD 1.67 Å
- 7EL1 chain A against the predicted model J7RUA5: TM-score 0.88, RMSD 3.32 Å
- 7EL1 chain A against the predicted model J7RUA5: TM-score 0.88, RMSD 3.32 Å
- 8Y0D chain A against the predicted model J7RUA5: TM-score 0.87, RMSD 3.76 Å
- 7VW3 chain A against the predicted model J7RUA5: TM-score 0.83, RMSD 3.04 Å
- 8JG9 chain D against the predicted model J7RUA5: TM-score 0.83, RMSD 4.95 Å
- 8JFT chain A against the predicted model J7RUA5: TM-score 0.83, RMSD 4.95 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.