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UniProt I7FC10

Dihydrofolate reductase (I7FC10)

Dihydrofolate reductase (UniProt I7FC10), EC 1.5.1.3: 4 experimental structures on GenesisL1, 4 ligands bound, 3 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt
I7FC10
Protein
Dihydrofolate reductase
EC
1.5.1.3
Experimental structures
4
Predicted models
0
Ligands
4
Pockets
3 · 2 records with a druggable one

Structures

4 records of I7FC10 in the MolNFT archive: 4 experimental, 0 predicted.

EntryTitleMethodChainsLigandsPockets
6CXMCrystal structure of a dihydrofolate reductase from Mycobacterium smegmatis in complex with NADP…x-ray diffractionA, BNAP, MMV2 (best 0.77)
6CXMCrystal structure of a dihydrofolate reductase from mycobacterium smegmatis in complex with NADP…x-ray diffractionA, BNAP, MMV—
7L9TCrystal Structure of Dihydrofolate reductase from Mycolicibacterium smegmatis in complex with…x-ray diffractionAQKJ, SO41 (best 0.68)
7L9TCrystal structure of dihydrofolate reductase from mycolicibacterium smegmatis in complex with…x-ray diffractionAQKJ, SO4—

Ligands

  • MMV · 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl) oxy]propoxy}phenyl)propanoic acid · in 2 records
  • NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 2 records
  • QKJ · 3-(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl) oxy]propoxy}phenyl)propanoic acid · in 2 records
  • SO4 · Sulfate ion · in 2 records

Elsewhere

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