UniProt I2N5E8
Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein,Aclacinomycin 10-hydroxylase RdmB (I2N5E8)
Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein,Aclacinomycin 10-hydroxylase RdmB (UniProt I2N5E8), EC 2.1.1.292, 4.1.1.-: 8 experimental structures on GenesisL1, 6 ligands bound, 26 pockets.…
- UniProt
- I2N5E8
- Protein
- Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing…
- EC
- 2.1.1.292, 4.1.1.-
- Experimental structures
- 8
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 26 · 4 records with a druggable one
Structures
8 records of I2N5E8 in the MolNFT archive: 8 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7OY1 | DnrK mutant RTCR | x-ray diffraction | A, B | SAH, 3VL | 6 (best 0.85) |
| 7OY1 | Dnrk mutant rtcr | x-ray diffraction | A, B | 3VL | — |
| 7PGA | Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-hydroxylase RdmB and… | x-ray diffraction | A, B, C, D | SAH, VAK | 12 (best 0.84) |
| 7PGA | Chimeric carminomycin-4-O-methyltransferase (dnrk) with regions from 10-hydroxylase rdmb and… | x-ray diffraction | A, B, C, D | VAK | — |
| 7PGJ | Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-decarboxylate TamK and… | x-ray diffraction | A | SAH, ZBX | 2 (best 0.77) |
| 7PGJ | Chimeric carminomycin-4-O-methyltransferase (dnrk) with regions from 10-decarboxylate tamk and… | x-ray diffraction | A | ZBX | — |
| 7PHD | Chimeric carminomycin-4-O-methyltransferase (DnrK) with a region from 10-decarboxylase TamK | x-ray diffraction | A, B | SO4, SAM, 3VL | 6 (best 0.83) |
| 7PHE | Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-hydroxylase RdmB and… | x-ray diffraction | A, B | VAK | — |
Ligands
- 3VL · methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate · in 3 records
- SAH · S-adenosyl-L-homocysteine · in 3 records
- VAK · methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate · in 3 records
- ZBX · methyl (1R,2R,4S)-2-ethyl-7-methoxy-2,4,5-tris(oxidanyl)-6,11-bis(oxidanylidene)-3,4-dihydro-1H-tetracene-1-carboxylate · in 2 records
- SAM · S-adenosylmethionine · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 7PHD chain A against the predicted model Q06528: TM-score 0.99, RMSD 0.72 Å
- 7PGA chain B against the predicted model Q06528: TM-score 0.97, RMSD 1.27 Å
- 7PGJ chain A against the predicted model Q06528: TM-score 0.97, RMSD 1.18 Å
- 7PHD chain B against the predicted model Q06528: TM-score 0.97, RMSD 1.14 Å
- 7PGA chain B against the predicted model Q06528: TM-score 0.97, RMSD 1.27 Å
- 7PGA chain C against the predicted model Q06528: TM-score 0.97, RMSD 1.23 Å
- 7PGJ chain A against the predicted model Q06528: TM-score 0.97, RMSD 1.18 Å
- 7PGA chain C against the predicted model Q06528: TM-score 0.97, RMSD 1.23 Å
- 7OY1 chain A against the predicted model Q06528: TM-score 0.96, RMSD 1.38 Å
- 7PGA chain A against the predicted model Q06528: TM-score 0.96, RMSD 1.35 Å
Elsewhere
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