UniProt H8XX12
Genome polyprotein (H8XX12)
Genome polyprotein (UniProt H8XX12), EC 3.4.21.91, 3.6.1.15: 17 experimental structures on GenesisL1, 8 ligands bound, 33 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- H8XX12
- Protein
- Genome polyprotein
- EC
- 3.4.21.91, 3.6.1.15, 3.6.4.13
- Experimental structures
- 17
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 33 · 6 records with a druggable one
Structures
17 records of H8XX12 in the MolNFT archive: 17 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5H6V | Structure of Zika virus protease in complex with a dipeptide inhibitor | x-ray diffraction | A, B | 7HS | 1 (best 0.42) |
| 5H6V | Structure of zika virus protease in complex with a dipeptide inhibitor | x-ray diffraction | A, B | — | — |
| 5ZMQ | Crystal structure of Zika NS3 protease with phenylacetyl-Lys-Lys-Arg-COOH inhibitor | x-ray diffraction | B, D, F, H | — | 5 (best 0.58) |
| 5ZMQ | Crystal structure of zika NS3 protease with phenylacetyl-lys-lys-arg- cooh inhibitor | x-ray diffraction | B, D, F, H | PAC | — |
| 5ZMS | Crystal structure of Zika NS3 protease in complex with 4-guanidinomethyl-phenylacetyl-Lys-Lys-Arg-H | x-ray diffraction | B, E, H, K | — | 8 (best 0.62) |
| 5ZMS | Crystal structure of zika NS3 protease in complex with 4- guanidinomethyl-phenylacetyl-lys-lys-arg-H | x-ray diffraction | B, E, H, K | 2UE | — |
| 6L4Z | Crystal structure of Zika NS2B-NS3 protease with compound 6 | x-ray diffraction | B, D, F, H | E5X | 6 (best 0.67) |
| 6L4Z | Crystal structure of zika NS2B-NS3 protease with compound 6 | x-ray diffraction | B, D, F, H | E5X | — |
| 6Y3B | Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2110 | x-ray diffraction | A, B | O7N, SO4 | — |
| 6Y3B | Crystal structure of unlinked NS2B-NS3 protease from zika virus in complex with inhibitor mi-2110 | x-ray diffraction | A, B | O7N, SO4 | — |
| 7DOC | Crystal structure of Zika NS2B-NS3 protease with compound 5 | x-ray diffraction | H | — | 3 (best 0.50) |
| 7DOC | Crystal structure of zika NS2B-NS3 protease with compound 5 | x-ray diffraction | H | — | — |
| 7O2M | Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2289 | x-ray diffraction | A, B | UZZ | 1 (best 0.40) |
| 7O2M | Crystal structure of unlinked NS2B-NS3 protease from zika virus in complex with inhibitor mi-2289 | x-ray diffraction | A, B | UZZ | — |
| 7VXX | Zika virus NS2B/NS3 protease bZipro(C143S) in complex with 4-amino benzamidine | x-ray diffraction | A, B, C, D | PBZ | 4 (best 0.58) |
| 7VXY | Zika virus NS2B/NS3 protease bZipro(C143S) in complex with D-RKOR | x-ray diffraction | A, B, C, D | — | 2 (best 0.60) |
| 8Y9V | ZIKV NS2B/NS3 protease | x-ray diffraction | A, C | — | 3 (best 0.61) |
Ligands
- E5X · 4-(hydroxymethyl)benzoic acid · in 2 records
- O7N · 1-[(8~{R},15~{S},18~{S})-15,18-bis(4-azanylbutyl)-4,7, 14,17,20-pentakis(oxidanylidene)-3,6,13,16,19-pentazabicyclo[20.3.1]hexacosa-1(25),22(26),23-trien-8-yl]guanidine · in 2 records
- SO4 · Sulfate ion · in 2 records
- UZZ · 1-[(3~{S},6~{S},9~{S},19~{R})-3,6-bis(4-azanylbutyl)-2, 5,8,12,15,18-hexakis(oxidanylidene)-9-(phenylmethyl)-1,4,7,11,14,17-hexazacyclotricos-19-yl]guanidine · in 2 records
- 2UE · 1-[4-(2-oxoethyl)benzyl]guanidine · in 1 record
- 7HS · (S)-2-acetamido-6-amino-N-((S)-5-guanidino-1-oxopentan-2-yl)hexanamide · in 1 record
- PAC · 2-phenylacetic acid · in 1 record
- PBZ · P-amino benzamidine · in 1 record
Elsewhere
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