UniProt H8EVV4
Isocitrate lyase 1 (H8EVV4)
Isocitrate lyase 1 (UniProt H8EVV4), EC 4.1.3.1, 4.1.3.30: 6 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 60 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- H8EVV4
- Protein
- Isocitrate lyase 1
- EC
- 4.1.3.1, 4.1.3.30
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 60 · 3 records with a druggable one
Structures
7 records of H8EVV4 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5DQL | Crystal Structure of 2-vinyl glyoxylate modified isocitrate lyase from Mycobacterium tuberculosis | x-ray diffraction | A, B, C, D | MG, VGX | 20 (best 0.89) |
| 5DQL | Crystal structure of 2-vinyl glyoxylate modified isocitrate lyase from mycobacterium tuberculosis | x-ray diffraction | A, B, C, D | — | — |
| 6C4A | Crystal structure of 3-nitropropionate modified isocitrate lyase from Mycobacterium tuberculosis… | x-ray diffraction | A, B, C, D, E, F, G, H | PYR, MG, 3NP | 20 (best 0.90) |
| 6C4A | Crystal structure of 3-nitropropionate modified isocitrate lyase from mycobacterium tuberculosis… | x-ray diffraction | A, B, C, D, E, F, G, H | PYR, MG, 3NP | — |
| 6C4C | Crystal structure of 3-nitropropionate modified isocitrate lyase from Mycobacterium tuberculosis… | x-ray diffraction | A, B, C, D, E, F, G, H | GLV, MG, PYR, 3NP | 20 (best 0.92) |
| 6C4C | Crystal structure of 3-nitropropionate modified isocitrate lyase from mycobacterium tuberculosis… | x-ray diffraction | A, B, C, D, E, F, G, H | GLV, MG, PYR, 3NP | — |
| H8EVV4 | AlphaFold monomer V2.0 prediction for isocitrate lyase 1 (H8EVV4) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6C4A chain G against the predicted model H8EVV4: TM-score 1.00, RMSD 0.41 Å
- 6C4A chain G against the predicted model H8EVV4: TM-score 1.00, RMSD 0.41 Å
- 6C4C chain G against the predicted model H8EVV4: TM-score 1.00, RMSD 0.42 Å
- 6C4C chain G against the predicted model H8EVV4: TM-score 1.00, RMSD 0.42 Å
- 6C4A chain B against the predicted model H8EVV4: TM-score 1.00, RMSD 0.42 Å
- 6C4A chain B against the predicted model H8EVV4: TM-score 1.00, RMSD 0.42 Å
- 6C4A chain D against the predicted model H8EVV4: TM-score 1.00, RMSD 0.43 Å
- 6C4A chain D against the predicted model H8EVV4: TM-score 1.00, RMSD 0.43 Å
- 6C4A chain C against the predicted model H8EVV4: TM-score 1.00, RMSD 0.43 Å
- 6C4A chain C against the predicted model H8EVV4: TM-score 1.00, RMSD 0.43 Å
Elsewhere
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