UniProt H3BCW1
ADP-ribosylhydrolase like 2 (H3BCW1)
ADP-ribosylhydrolase like 2 (UniProt H3BCW1), EC 3.2.1.143, 3.2.2.-: 16 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 33 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- H3BCW1
- Protein
- ADP-ribosylhydrolase like 2
- EC
- 3.2.1.143, 3.2.2.-, 3.5.1.-
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 33 · 7 records with a druggable one
Structures
17 records of H3BCW1 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G1P | Apo form of ADP-ribosylserine hydrolase ARH3 of Latimeria chalumnae | x-ray diffraction | A, B | MG | 6 (best 0.84) |
| 6G1P | Apo form of ADP-ribosylserine hydrolase ARH3 of latimeria chalumnae | x-ray diffraction | A, B | MG | — |
| 6G1Q | ADP-ribosylserine hydrolase ARH3 of Latimeria chalumnae in complex with ADP-ribose | x-ray diffraction | A, B | MG, AR6 | 6 (best 0.87) |
| 6G1Q | ADP-ribosylserine hydrolase ARH3 of latimeria chalumnae in complex with ADP-ribose | x-ray diffraction | A, B | MG, AR6 | — |
| 6HGZ | ADP-ribosylserine hydrolase ARH3 of Latimeria chalumnae in complex with ADP-ribose | x-ray diffraction | A, B | MG, AR6 | 4 (best 0.87) |
| 6HGZ | ADP-ribosylserine hydrolase ARH3 of latimeria chalumnae in complex with ADP-ribose | x-ray diffraction | A, B | MG, AR6 | — |
| 6HH3 | ADP-ribosylserine hydrolase ARH3 of Latimeria chalumnae in complex with ADP-HPD | x-ray diffraction | A, B | MG, A1R | 5 (best 0.87) |
| 6HH3 | ADP-ribosylserine hydrolase ARH3 of latimeria chalumnae in complex with ADP-hpd | x-ray diffraction | A, B | MG, A1R | — |
| 6HH4 | ADP-ribosylserine hydrolase ARH3 of Latimeria chalumnae in complex with ADP-ribosyl-L-arginine | x-ray diffraction | A, B | MG, F2R | 5 (best 0.88) |
| 6HH4 | ADP-ribosylserine hydrolase ARH3 of latimeria chalumnae in complex with ADP-ribosyl-L-arginine | x-ray diffraction | A, B | MG, F2R | — |
| 6HH5 | ADP-ribosylserine hydrolase ARH3 of Latimeria chalumnae in complex with ADP-HPM | x-ray diffraction | A, B | MG, A3R | 4 (best 0.87) |
| 6HH5 | ADP-ribosylserine hydrolase ARH3 of latimeria chalumnae in complex with ADP-hpm | x-ray diffraction | A, B | MG, A3R | — |
| 6HOZ | ADP-ribosylserine hydrolase ARH3 of Latimeria chalumnae in complex with inosine diphosphate ribose… | x-ray diffraction | A, B | MG, R5I, R7I | — |
| 6HOZ | ADP-ribosylserine hydrolase ARH3 of latimeria chalumnae in complex with inosine diphosphate ribose… | x-ray diffraction | A, B | MG, R5I, R7I | — |
| 7AQM | ADP-ribosylserine hydrolase ARH3 of Latimeria chalumnae in complex with… | x-ray diffraction | A, B | MG, RVK | 3 (best 0.87) |
| 7AQM | ADP-ribosylserine hydrolase ARH3 of latimeria chalumnae in complex with… | x-ray diffraction | A, B | MG, RVK | — |
| H3BCW1 | AlphaFold monomer V2.0 prediction for ADP-ribose glycohydrolase ARH3 (H3BCW1) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 16 records
- AR6 · [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [hydroxy-[[(2R,3S,4R,5S)-3,4,5-trihydroxyoxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate · in 4 records
- A1R · 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy) phosphoryl]adenosine · in 2 records
- A3R · Adenosine Diphosphate (Hydroxymethyl)pyrrolidine monoalcohol · in 2 records
- F2R · ADP-ribosyl-L-arginine · in 2 records
- R5I · inosine diphosphate ribose · in 2 records
- R7I · inosine diphosphate ribose · in 2 records
- RVK · Adenosine 5'-diphosphoric acid beta-[(3beta,4beta-dihydroxy-5beta-methoxytetrahydrofuran-2alpha-yl) methyl] estere · in 2 records
Experiment against prediction
- 6HH5 chain B against the predicted model H3BCW1: TM-score 0.99, RMSD 0.95 Å
- 6HH5 chain B against the predicted model H3BCW1: TM-score 0.99, RMSD 0.95 Å
- 6HGZ chain A against the predicted model H3BCW1: TM-score 0.99, RMSD 0.95 Å
- 6HGZ chain A against the predicted model H3BCW1: TM-score 0.99, RMSD 0.95 Å
- 6HH3 chain A against the predicted model H3BCW1: TM-score 0.99, RMSD 0.96 Å
- 6HH3 chain A against the predicted model H3BCW1: TM-score 0.99, RMSD 0.96 Å
- 6HOZ chain B against the predicted model H3BCW1: TM-score 0.99, RMSD 0.97 Å
- 6HOZ chain B against the predicted model H3BCW1: TM-score 0.99, RMSD 0.97 Å
- 7AQM chain B against the predicted model H3BCW1: TM-score 0.99, RMSD 0.96 Å
- 7AQM chain B against the predicted model H3BCW1: TM-score 0.99, RMSD 0.96 Å
Elsewhere
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