UniProt G3ECR2
CRISPR-associated endonuclease Cas1 (G3ECR2)
CRISPR-associated endonuclease Cas1 (UniProt G3ECR2), EC 3.1.-.-: 8 experimental structures and 1 predicted model on GenesisL1, 80 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- G3ECR2
- Protein
- CRISPR-associated endonuclease Cas1
- EC
- 3.1.-.-
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 80 · 5 records with a druggable one
Structures
9 records of G3ECR2 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6QXF | Cas1-Cas2-Csn2-DNA complex from the Type II-A CRISPR-Cas system | electron microscopy | I, J, L, M, O, P, R, S | — | 13 (best 0.81) |
| 6QXF | CAS1-CAS2-CSN2-DNA complex from the type II-a CRISPR-CAS system | electron microscopy | I, J, L, M, O, P, R, S | — | — |
| 6QXT | Cas1-Cas2-Csn2-DNA dimer complex from the Type II-A CRISPR-Cas system | electron microscopy | I, J, L, M, O, P, R, S, U, V, Y, Z, i, j, l, m, o, p, r, s, u, v, y, z | — | 16 (best 0.83) |
| 6QXT | CAS1-CAS2-CSN2-DNA dimer complex from the type II-a CRISPR-CAS system | electron microscopy | I, J, L, M, O, P, R, S, U, V, Y, Z, i, j, l, m, o, p, r, s, u, v, y, z | — | — |
| 6QY3 | Segment of the Cas1-Cas2-Csn2-DNA filament complex from the Type II-A CRISPR-Cas system | electron microscopy | I, J, L, M, O, P, R, S, U, V, Y, Z, i, j, l, m, o, p, r, s, u, v, y, z | — | 18 (best 0.83) |
| 6QY3 | Segment of the CAS1-CAS2-CSN2-DNA filament complex from the type II-a CRISPR-CAS system | electron microscopy | I, J, L, M, O, P, R, S, U, V, Y, Z, i, j, l, m, o, p, r, s, u, v, y, z | — | — |
| 8PK1 | Cas1-Cas2 CRISPR integrase bound to prespacer DNA, Streptococcus thermophilus DGCC 7710 CRISPR3… | electron microscopy | B, C, E, F | — | 15 (best 0.77) |
| 8Q2N | Cas1-Cas2 CRISPR integrase bound to prespacer and target DNA, Streptococcus thermophilus DGCC 7710… | electron microscopy | B, C, E, F | — | 18 (best 0.81) |
| G3ECR2 | AlphaFold monomer V2.0 prediction for CRISPR-associated endonuclease CAS1 (G3ECR2) | predicted | A | — | — |
Experiment against prediction
- 8PK1 chain E against the predicted model G3ECR2: TM-score 0.98, RMSD 0.94 Å
- 8PK1 chain B against the predicted model G3ECR2: TM-score 0.98, RMSD 0.94 Å
- 8Q2N chain E against the predicted model G3ECR2: TM-score 0.97, RMSD 1.07 Å
- 8Q2N chain B against the predicted model G3ECR2: TM-score 0.97, RMSD 1.07 Å
- 6QY3 chain v against the predicted model G3ECR2: TM-score 0.97, RMSD 1.28 Å
- 6QXT chain s against the predicted model G3ECR2: TM-score 0.97, RMSD 1.28 Å
- 6QXT chain s against the predicted model G3ECR2: TM-score 0.97, RMSD 1.28 Å
- 6QXT chain z against the predicted model G3ECR2: TM-score 0.97, RMSD 1.28 Å
- 6QXT chain Z against the predicted model G3ECR2: TM-score 0.97, RMSD 1.28 Å
- 6QXT chain Z against the predicted model G3ECR2: TM-score 0.97, RMSD 1.28 Å
Elsewhere
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