UniProt F6DES6
(P)ppGpp synthetase I, SpoT/RelA (F6DES6)
(P)ppGpp synthetase I, SpoT/RelA (UniProt F6DES6), EC 2.7.6.5: 6 experimental structures on GenesisL1, 9 ligands bound, 21 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- F6DES6
- Protein
- (P)ppGpp synthetase I, SpoT/RelA
- EC
- 2.7.6.5
- Experimental structures
- 6
- Predicted models
- 0
- Ligands
- 9
- Pockets
- 21 · 3 records with a druggable one
Structures
6 records of F6DES6 in the MolNFT archive: 6 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6S2T | Structure of the N-terminal catalytic region of T. thermophilus Rel bound to ppGpp | x-ray diffraction | A | G4P, MN, MG, CL | 4 (best 0.61) |
| 6S2T | Structure of the N-terminal catalytic region of T. thermophilus rel bound to ppgpp | x-ray diffraction | A | G4P, MN, MG, CL | — |
| 6S2U | Structure of the catalytic domain of T. thermophilus Rel in complex with AMP and ppGpp | x-ray diffraction | A | MN, AMP, GN3, TMO, MG | 4 (best 0.51) |
| 6S2U | Structure of the catalytic domain of T. thermophilus rel in complex with AMP and ppgpp | x-ray diffraction | A | MN, AMP, GN3, MG | — |
| 6S2V | Structure of the N-terminal catalytic region of T. thermophilus Rel | x-ray diffraction | A, B, C | MN, CL, PO4, NA | 13 (best 0.71) |
| 6S2V | Structure of the N-terminal catalytic region of T. thermophilus rel | x-ray diffraction | A, B, C | MN, CL, PO4, NA | — |
Ligands
- MN · Manganese (II) ion · in 6 records
- CL · Chloride ion · in 4 records
- MG · Magnesium ion · in 4 records
- AMP · Adenosine monophosphate · in 2 records
- G4P · Guanosine-5',3'-tetraphosphate · in 2 records
- GN3 · [[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-oxidanyl-2-[[oxidanyl(phosphonooxy)phosphoryl]oxymethyl]oxolan-3-yl]oxy-oxidanyl-phosphoryl]amino]phosphonic acid · in 2 records
- NA · Sodium ion · in 2 records
- PO4 · Phosphate ion · in 2 records
- TMO · trimethylamine oxide · in 1 record
Elsewhere
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