UniProt F2WR39
Integrase (F2WR39)
Integrase (UniProt F2WR39), EC 2.7.7.-: 18 experimental structures on GenesisL1, 11 ligands bound, 83 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- F2WR39
- Protein
- Integrase
- EC
- 2.7.7.-
- Experimental structures
- 18
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 83 · 5 records with a druggable one
Structures
18 records of F2WR39 in the MolNFT archive: 18 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4TSX | HIV-1 Integrase Catalytic Core Domain Mutant Complexed with Allosteric Inhibitor | x-ray diffraction | A | — | — |
| 4TSX | HIV-1 integrase catalytic core domain mutant complexed with allosteric inhibitor | x-ray diffraction | A | — | — |
| 4Y1D | Cyclic hexapeptide cyc[NdPopPKID] in complex with HIV-1 integrase core domain | x-ray diffraction | A, B | — | — |
| 4Y1D | Cyclic hexapeptide CYC[NDPOPPKID] in complex with HIV-1 integrase core domain | x-ray diffraction | A, B | — | — |
| 5U1C | Structure of tetrameric HIV-1 Strand Transfer Complex Intasome | electron microscopy | A, B, C, D | ZN, MG | 20 (best 0.73) |
| 5U1C | Structure of tetrameric HIV-1 strand transfer complex intasome | electron microscopy | A, B, C, D | ZN, MG | — |
| 6VDK | CryoEM structure of HIV-1 conserved Intasome Core | electron microscopy | A, B, C, D, I, J, M, P | MG, DLU | 20 (best 0.83) |
| 6VDK | Cryoem structure of HIV-1 conserved intasome core | electron microscopy | A, B, C, D, I, J, M, P | MG, DLU | — |
| 6VKA | HIV Integrase Core domain (IN) in complex with dimer-spanning ligand | x-ray diffraction | A, B | IOD, QZV, SO4 | 5 (best 0.62) |
| 6VKA | HIV integrase core domain (in) in complex with dimer-spanning ligand | x-ray diffraction | A, B | IOD, QZV, SO4 | — |
| 6VLH | HIV Integrase Core domain (IN) in complex with dimer-spanning ligand | x-ray diffraction | A, B | IOD, SO4, R2A | — |
| 6VLH | HIV integrase core domain (in) in complex with dimer-spanning ligand | x-ray diffraction | A, B | IOD, SO4, R2A | — |
| 6VRG | Structure of HIV-1 integrase with native amino-terminal sequence | x-ray diffraction | A, B, C, D | ZN, K, PO4 | — |
| 6VX2 | HIV Integrase core domain in complex with inhibitor (5-methyl-1-benzofuran-3-yl)acetic acid | x-ray diffraction | A | IOD, RQG, SO4 | 1 (best 0.32) |
| 6VX2 | HIV integrase core domain in complex with inhibitor (5-methyl-1- benzofuran-3-YL)ACETIC acid | x-ray diffraction | A | IOD, RQG, SO4 | — |
| 6W0U | HIV integrase core domain in complex with inhibitor 2-(2-ethynyl-5- methyl-1-benzofuran-3-YL)ACETIC… | x-ray diffraction | A | S0Y, SO4, IOD | — |
| 8W2R | HIV-1 P5-IN intasome core | electron microscopy | A, B, C, D, I, K, L, M | MG, ZN, DLU | 17 (best 0.83) |
| 8W34 | HIV-1 intasome core assembled with wild-type integrase, 1F | electron microscopy | A, B, C, D, I, K, L, M | ZN, DLU, MG | 20 (best 0.76) |
Ligands
- IOD · Iodide ion · in 7 records
- SO4 · Sulfate ion · in 7 records
- MG · Magnesium ion · in 6 records
- ZN · Zinc ion · in 5 records
- DLU · (4r,12as)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6, 8-dioxo-3,4,6,8,12,12A-hexahydro-2H-pyrido[1',2':4, 5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide · in 4 records
- QZV · 2,2'-{ethane-1,2-diylbis[oxyethane-2,1-diylcarbamoyl-4, 1-phenyleneethyne-2,1-diyl(5-methyl-1-benzofuran-2,3-diyl)]}diacetic acid · in 2 records
- R2A · (2-{[3-(4-{2-[(3-{[3-(carboxymethyl)-5-methyl-1-benzofuran-2-yl]ethynyl}benzene-1-carbonyl) amino]ethyl}piperazine-1-carbonyl)phenyl]ethynyl}-5-methyl-1-benzofuran-3-yl)acetic acid · in 2 records
- RQG · (5-methyl-1-benzofuran-3-yl)acetic acid · in 2 records
- K · Potassium ion · in 1 record
- PO4 · Phosphate ion · in 1 record
- S0Y · 2-(2-ethynyl-5-methyl-1-benzofuran-3-yl)ethanoic acid · in 1 record
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.