UniProt D9N170
Bifunctional dihydrofolate reductase-thymidylate synthase (D9N170)
Bifunctional dihydrofolate reductase-thymidylate synthase (UniProt D9N170): 32 experimental structures on GenesisL1, 17 ligands bound, 96 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- D9N170
- Protein
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Experimental structures
- 32
- Predicted models
- 0
- Ligands
- 17
- Pockets
- 96 · 6 records with a druggable one
Structures
32 records of D9N170 in the MolNFT archive: 32 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3QG2 | Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex | x-ray diffraction | A, B | — | — |
| 3QG2 | Plasmodium falciparum DHFR-ts qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex | x-ray diffraction | A, B | — | — |
| 4DP3 | Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | — | — |
| 4DP3 | Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | — | — |
| 4DPH | Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | — | — |
| 4DPH | Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | — | — |
| 6A2L | Crystal structure of quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum DHFR-TS… | x-ray diffraction | A, B | 9QO, NAP, UMP | 17 (best 0.73) |
| 6A2L | Crystal structure of quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum DHFR-ts… | x-ray diffraction | A, B | 9QO, NAP, UMP | — |
| 6A2N | Crystal structure of quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum DHFR-TS… | x-ray diffraction | A, B | 9QR, NAP, UMP | 14 (best 0.73) |
| 6A2N | Crystal structure of quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum DHFR-ts… | x-ray diffraction | A, B | 9QR, NAP, UMP | — |
| 6A2P | Crystal structure of quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum DHFR-TS… | x-ray diffraction | A, B | 9RR, NAP, UMP | 18 (best 0.72) |
| 6A2P | Crystal structure of quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum DHFR-ts… | x-ray diffraction | A, B | 9RR, NAP, UMP | — |
| 6KOT | Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | DQ0, NDP, UMP | — |
| 6KOT | Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | DQ0, NDP, UMP | — |
| 6KP2 | Quadruple mutant plasmodium falciparum dihydrofolate reductase complexed with B10042 | x-ray diffraction | A, B | NDP, DQ3, PO4 | — |
| 6KP2 | Quadruple mutant plasmodium falciparum dihydrofolate reductase complexed with B10042 | x-ray diffraction | A, B | NDP, DQ3, PO4 | — |
| 6KP7 | Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | NDP, UMP, DQ9 | — |
| 6KP7 | Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | NDP, UMP, DQ9 | — |
| 6KPR | Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | UMP, NDP, DQF | — |
| 6KPR | Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | UMP, NDP, DQF | — |
| 6LEU | Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | UMP, NDP, E9X | — |
| 6LEU | Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | UMP, NDP, E9X | — |
| 6LEV | Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | EA0, NDP, PO4 | — |
| 6LEZ | Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | EA0, NDP, PO4 | — |
| 6LH9 | Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | PO4, EA0, NDP | — |
| 6LHI | Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | UMP, E9X, NDP | — |
| 6LHI | Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | UMP, E9X, NDP | — |
| 6LHJ | Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | EA6, NDP, UMP | — |
| 6LHJ | Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate… | x-ray diffraction | A, B | EA6, NDP, UMP | — |
| 8JFB | V1/S quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase… | x-ray diffraction | A, B | U86, NDP, UMP | 17 (best 0.73) |
| 8JFC | V1/S quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase… | x-ray diffraction | A, B | NDP, UMP, U8I | 15 (best 0.73) |
| 8JFD | V1/S quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase… | x-ray diffraction | A, B | NDP, UMP, U8Y | 15 (best 0.75) |
Ligands
- UMP · 2'-deoxyuridine 5'-monophosphate · in 21 records
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 20 records
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 6 records
- PO4 · Phosphate ion · in 5 records
- E9X · 1-[3-[(4-chlorophenyl)-(phenylmethyl)amino]propoxy]-6, 6-dimethyl-1,3,5-triazine-2,4-diamine · in 4 records
- EA0 · 2-[[4,6-bis(azanyl)-2,2-dimethyl-1,3,5-triazin-1-yl]oxy]-N-(4-chlorophenyl)ethanamide · in 3 records
- 9QO · 5-(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl) oxy]propoxy}phenyl)-6-ethylpyrimidine-2,4-diamine · in 2 records
- 9QR · 5-(4-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl) oxy]propoxy}phenyl)-6-ethylpyrimidine-2,4-diamine · in 2 records
- 9RR · 5,5'-[propane-1,3-diylbis(oxy-4,1-phenylene)]bis(6-ethylpyrimidine-2,4-diamine) · in 2 records
- DQ0 · 4-[3-[[2,6-bis(azanyl)-5-(3-chlorophenyl)pyrimidin-4-yl]methoxy]phenoxy]butanoic acid · in 2 records
- DQ3 · 5-(3-chlorophenyl)-6-(3-phenoxypropyl)pyrimidine-2,4-diamine · in 2 records
- DQ9 · 2-[3-[3-[2,6-bis(azanyl)-5-(3-chlorophenyl)pyrimidin-4-yl]propoxy]phenoxy]ethanoic acid · in 2 records
- DQF · 4-[3-[3-[2,6-bis(azanyl)-5-(3-chlorophenyl)pyrimidin-4-yl]propoxy]phenoxy]butanoic acid · in 2 records
- EA6 · 1-[3-(2-chloranyl-4-fluoranyl-phenoxy)propoxy]-6,6-dimethyl-1,3,5-triazine-2,4-diamine · in 2 records
- U86 · 3-[4-[[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]methyl]phenyl]benzoic acid · in 1 record
- U8I · 4-[3-[[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]methyl]phenyl]benzoic acid · in 1 record
- U8Y · 3-[3-[[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]methyl]phenyl]benzoic acid · in 1 record
Elsewhere
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