UniProt C6KSX0
Merozoite surface protein P12 (C6KSX0)
Merozoite surface protein P12 (UniProt C6KSX0): 8 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- C6KSX0
- Protein
- Merozoite surface protein P12
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 6 · 1 record with a druggable one
Structures
9 records of C6KSX0 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2LOE | Structure of the Plasmodium 6-cysteine s48/45 Domain | solution nmr | A | — | — |
| 2LOE | Structure of the plasmodium 6-cysteine S48/45 domain | solution nmr | A | — | — |
| 2YMO | Crystal structure of Pf12 tandem 6-cys domains from Plasmodium falciparum | x-ray diffraction | A | — | — |
| 2YMO | Crystal structure of PF12 tandem 6-cys domains from plasmodium falciparum | x-ray diffraction | A | — | — |
| 7S7Q | Heterodimeric complex of Pf12 and Pf41 of Plasmodium falciparum | x-ray diffraction | B | CD, NAG | 2 (best 0.71) |
| 7S7Q | Heterodimeric complex of PF12 and PF41 of plasmodium falciparum | x-ray diffraction | B | CD, NAG | — |
| 7S7R | Plasmodium falciparum protein Pf12 bound to nanobody G7 | x-ray diffraction | A | NAG, SCN | 2 (best 0.45) |
| 7S7R | Plasmodium falciparum protein PF12 bound to nanobody G7 | x-ray diffraction | A | NAG, SCN | — |
| C6KSX0 | AlphaFold monomer V2.0 prediction for merozoite surface protein P12 (C6KSX0) | predicted | A | — | 2 (best 0.35) |
Ligands
Experiment against prediction
- 2YMO chain A against the predicted model C6KSX0: TM-score 0.97, RMSD 1.21 Å
- 2YMO chain A against the predicted model C6KSX0: TM-score 0.97, RMSD 1.21 Å
- 7S7R chain A against the predicted model C6KSX0: TM-score 0.95, RMSD 1.52 Å
- 7S7R chain A against the predicted model C6KSX0: TM-score 0.95, RMSD 1.52 Å
- 7S7Q chain B against the predicted model C6KSX0: TM-score 0.89, RMSD 2.33 Å
- 7S7Q chain B against the predicted model C6KSX0: TM-score 0.89, RMSD 2.33 Å
- 2LOE chain A against the predicted model C6KSX0: TM-score 0.84, RMSD 2.16 Å
- 2LOE chain A against the predicted model C6KSX0: TM-score 0.84, RMSD 2.16 Å
Elsewhere
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