UniProt C5MKY7
Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera (C5MKY7)
Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera (UniProt C5MKY7): 4 experimental structures on GenesisL1, 6 ligands bound, 60 pockets. Binding sites, pockets…
- UniProt
- C5MKY7
- Protein
- Transient receptor potential cation channel subfamily V member 4/Enhanced green…
- Experimental structures
- 4
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 60 · 3 records with a druggable one
Structures
4 records of C5MKY7 in the MolNFT archive: 4 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EEB | Structure of the catspermasome | electron microscopy | A | NA, 9Z9 | — |
| 8T1B | Cryo-EM structure of full-length human TRPV4 in apo state | electron microscopy | A, B, C, D | 9ZR, YJ0, NA | 20 (best 0.79) |
| 8T1E | Closed-state cryo-EM structure of full-length human TRPV4 in the presence of 4a-PDD | electron microscopy | A, B, C, D | 9ZR, YJ0, NA | 20 (best 0.82) |
| 8T1F | Cryo-EM structure of full-length human TRPV4 in complex with antagonist HC-067047 | electron microscopy | A, B, C, D | X7N, POV | 20 (best 0.80) |
Ligands
- NA · Sodium ion · in 3 records
- 9ZR · [(2~{R})-2-[(~{Z})-hexadec-9-enoyl]oxy-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] (~{Z})-docos-13-enoate · in 2 records
- YJ0 · (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside · in 2 records
- 9Z9 · (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en · in 1 record
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 1 record
- X7N · 2-methyl-1-[3-(morpholin-4-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide · in 1 record
Experiment against prediction
- 7EEB chain A against the predicted model Q91ZR5: TM-score 0.74, RMSD 3.75 Å
Elsewhere
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