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UniProt C3S7P8

Bifunctional dihydrofolate reductase-thymidylate synthase (C3S7P8)

Bifunctional dihydrofolate reductase-thymidylate synthase (UniProt C3S7P8): 2 experimental structures on GenesisL1, 3 ligands bound, 17 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt
C3S7P8
Protein
Bifunctional dihydrofolate reductase-thymidylate synthase
Experimental structures
2
Predicted models
0
Ligands
3
Pockets
17 · 1 record with a druggable one

Structures

2 records of C3S7P8 in the MolNFT archive: 2 experimental, 0 predicted.

EntryTitleMethodChainsLigandsPockets
7F3ZDouble mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-K1…x-ray diffractionA, BNDP, UMP, TOP17 (best 0.76)
7F3ZDouble mutant plasmodium falciparum dihydrofolate reductase- thymidylate synthase (pfdhfr-ts-K1…x-ray diffractionA, BNDP, UMP, TOP—

Ligands

  • NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 2 records
  • TOP · Trimethoprim · in 2 records
  • UMP · 2'-deoxyuridine 5'-monophosphate · in 2 records

Elsewhere

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