UniProt B8ZKS5
Leucine--tRNA ligase (B8ZKS5)
Leucine--tRNA ligase (UniProt B8ZKS5), EC 6.1.1.4: 6 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- B8ZKS5
- Protein
- Leucine--tRNA ligase
- EC
- 6.1.1.4
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 7 · 2 records with a druggable one
Structures
7 records of B8ZKS5 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4K47 | Structure of the Streptococcus pneumoniae leucyl-tRNA synthetase editing domain bound to a… | x-ray diffraction | A | — | — |
| 4K47 | Structure of the streptococcus pneumoniae leucyl-tRNA synthetase editing domain bound to a… | x-ray diffraction | A | — | — |
| 4K48 | Structure of the Streptococcus pneumoniae leucyl-tRNA synthetase editing domain | x-ray diffraction | A | — | — |
| 4K48 | Structure of the streptococcus pneumoniae leucyl-tRNA synthetase editing domain | x-ray diffraction | A | — | — |
| 7BZJ | The Discovery of Benzhydrol-Oxaborole Hybrid Derivatives as Leucyl-tRNA Synthetase Inhibitors | x-ray diffraction | A | FGX | 1 (best 0.58) |
| 7BZJ | The discovery of benzhydrol-oxaborole hybrid derivatives as leucyl- tRNA synthetase inhibitors | x-ray diffraction | A | FGX | — |
| B8ZKS5 | AlphaFold monomer V2.0 prediction for leucine--tRNA ligase (B8ZKS5) | predicted | A | — | 6 (best 0.73) |
Ligands
- FGX · [(1~{R},5~{R},6~{S},8~{R})-8-(6-aminopurin-9-yl)-4'-[(~{R})-oxidanyl-[4-(2-oxidanylidenepropylsulfanyl) phenyl]methyl]spiro[2,4,7-trioxa-3-boranuidabicyclo[3.3.0]octane-3,7'-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-triene]-6-yl]methoxy-tris(oxidanyl)phosphanium · in 2 records
Experiment against prediction
- 7BZJ chain A against the predicted model B8ZKS5: TM-score 0.98, RMSD 0.78 Å
- 7BZJ chain A against the predicted model B8ZKS5: TM-score 0.98, RMSD 0.78 Å
- 4K47 chain A against the predicted model B8ZKS5: TM-score 0.98, RMSD 0.79 Å
- 4K47 chain A against the predicted model B8ZKS5: TM-score 0.98, RMSD 0.79 Å
- 4K48 chain A against the predicted model B8ZKS5: TM-score 0.98, RMSD 0.88 Å
- 4K48 chain A against the predicted model B8ZKS5: TM-score 0.98, RMSD 0.88 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.