UniProt B7QK46
Glutaminyl-peptide cyclotransferase (B7QK46)
Glutaminyl-peptide cyclotransferase (UniProt B7QK46), EC 2.3.2.5: 28 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 28 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- B7QK46
- Protein
- Glutaminyl-peptide cyclotransferase
- EC
- 2.3.2.5
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 28 · 4 records with a druggable one
Structures
29 records of B7QK46 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4MHN | Crystal structure of a glutaminyl cyclase from Ixodes scapularis | x-ray diffraction | A | — | — |
| 4MHN | Crystal structure of a glutaminyl cyclase from ixodes scapularis | x-ray diffraction | A | — | — |
| 4MHP | Crystal structure of apo-form of glutaminyl cyclase from Ixodes scapularis | x-ray diffraction | A | — | — |
| 4MHP | Crystal structure of apo-form of glutaminyl cyclase from ixodes scapularis | x-ray diffraction | A | — | — |
| 4MHY | Crystal structure of a glutaminyl cyclase from Ixodes scapularis in complex with PBD150 | x-ray diffraction | A | — | — |
| 4MHY | Crystal structure of a glutaminyl cyclase from ixodes scapularis in complex with PBD150 | x-ray diffraction | A | — | — |
| 4MHZ | Crystal structure of apo-form glutaminyl cyclase from Ixodes scapularis in complex with PBD150 | x-ray diffraction | A | — | — |
| 4MHZ | Crystal structure of apo-form glutaminyl cyclase from ixodes scapularis in complex with PBD150 | x-ray diffraction | A | — | — |
| 7D1H | Crystal structure of Ixodes scapularis glutaminyl cyclase with D238A mutation | x-ray diffraction | A | ZN | 2 (best 0.48) |
| 7D1H | Crystal structure of ixodes scapularis glutaminyl cyclase with D238A mutation | x-ray diffraction | A | ZN | — |
| 7D1N | Crystal structure of Ixodes scapularis glutaminyl cyclase with three Cu ions bound to the active… | x-ray diffraction | A | CU, BCT | 3 (best 0.68) |
| 7D1N | Crystal structure of ixodes scapularis glutaminyl cyclase with three cu ions bound to the active… | x-ray diffraction | A | CU, BCT | — |
| 7D1P | Crystal structure of Ixodes scapularis glutaminyl cyclase with three Cd ions bound to the active… | x-ray diffraction | A | CD, BCT | 4 (best 0.51) |
| 7D1P | Crystal structure of ixodes scapularis glutaminyl cyclase with three CD ions bound to the active… | x-ray diffraction | A | CD, BCT | — |
| 7D1Y | Crystal structure of Ixodes scapularis glutaminyl cyclase with two Co ions bound to the active site | x-ray diffraction | A | CO | 2 (best 0.50) |
| 7D1Y | Crystal structure of ixodes scapularis glutaminyl cyclase with two co ions bound to the active site | x-ray diffraction | A | CO | — |
| 7D21 | Crystal structure of Ixodes scapularis glutaminyl cyclase with two Zn ions bound to the active site | x-ray diffraction | A | ZN | 2 (best 0.47) |
| 7D21 | Crystal structure of ixodes scapularis glutaminyl cyclase with two zn ions bound to the active site | x-ray diffraction | A | ZN | — |
| 7D23 | Crystal structure of Ixodes scapularis glutaminyl cyclase with one K ion bound to the active site | x-ray diffraction | A | K | 2 (best 0.46) |
| 7D23 | Crystal structure of ixodes scapularis glutaminyl cyclase with one K ion bound to the active site | x-ray diffraction | A | K | — |
| 7D2B | Crystal structure of Ixodes scapularis glutaminyl cyclase with a Ni ion bound to the active site | x-ray diffraction | A | NI | 3 (best 0.45) |
| 7D2B | Crystal structure of ixodes scapularis glutaminyl cyclase with a ni ion bound to the active site | x-ray diffraction | A | NI | — |
| 7D2D | Crystal structure of Ixodes scapularis glutaminyl cyclase with a Mn ion bound to the active site | x-ray diffraction | A | MN | 3 (best 0.45) |
| 7D2D | Crystal structure of ixodes scapularis glutaminyl cyclase with a mn ion bound to the active site | x-ray diffraction | A | MN | — |
| 7D2I | Crystal structure of Ixodes scapularis glutaminyl cyclase with a Fe ion bound to the active site | x-ray diffraction | A | FE, SO4 | 2 (best 0.43) |
| 7D2I | Crystal structure of ixodes scapularis glutaminyl cyclase with a fe ion bound to the active site | x-ray diffraction | A | FE, SO4 | — |
| 7D2J | Crystal structure of Ixodes scapularis glutaminyl cyclase with a Cd ion bound to the active site | x-ray diffraction | A | CD, BCT | 2 (best 0.45) |
| 7D2J | Crystal structure of ixodes scapularis glutaminyl cyclase with a CD ion bound to the active site | x-ray diffraction | A | CD, BCT | — |
| B7QK46 | AlphaFold monomer V2.0 prediction for glutaminyl-peptide cyclotransferase (B7QK46) | predicted | A | — | 3 (best 0.55) |
Ligands
- BCT · Bicarbonate ion · in 6 records
- CD · Cadmium ion · in 4 records
- ZN · Zinc ion · in 4 records
- CO · Cobalt (II) ion · in 2 records
- CU · Copper (II) ion · in 2 records
- FE · Fe (III) ion · in 2 records
- K · Potassium ion · in 2 records
- MN · Manganese (II) ion · in 2 records
- NI · Nickel (II) ion · in 2 records
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 4MHP chain A against the predicted model B7QK46: TM-score 1.00, RMSD 0.17 Å
- 4MHP chain A against the predicted model B7QK46: TM-score 1.00, RMSD 0.17 Å
- 4MHN chain A against the predicted model B7QK46: TM-score 1.00, RMSD 0.17 Å
- 4MHN chain A against the predicted model B7QK46: TM-score 1.00, RMSD 0.17 Å
- 4MHY chain A against the predicted model B7QK46: TM-score 1.00, RMSD 0.18 Å
- 4MHY chain A against the predicted model B7QK46: TM-score 1.00, RMSD 0.18 Å
- 7D2D chain A against the predicted model B7QK46: TM-score 1.00, RMSD 0.19 Å
- 7D2D chain A against the predicted model B7QK46: TM-score 1.00, RMSD 0.19 Å
- 7D2B chain A against the predicted model B7QK46: TM-score 1.00, RMSD 0.20 Å
- 7D2B chain A against the predicted model B7QK46: TM-score 1.00, RMSD 0.20 Å
Elsewhere
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