UniProt B7IE18
Lipid II flippase MurJ (B7IE18)
Lipid II flippase MurJ (UniProt B7IE18): 9 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- B7IE18
- Protein
- Lipid II flippase MurJ
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 14 · 2 records with a druggable one
Structures
10 records of B7IE18 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5T77 | Crystal structure of the mop flippase murj | x-ray diffraction | A | CL, ZN, CA, NA, OLB | — |
| 6NC6 | Lipid II flippase MurJ, inward closed conformation | x-ray diffraction | A, B | NA, CL, ZN, OLB | 9 (best 0.82) |
| 6NC6 | Lipid II flippase murj, inward closed conformation | x-ray diffraction | A, B | NA, CL, ZN, OLB | — |
| 6NC7 | Lipid II flippase MurJ, inward open conformation | x-ray diffraction | A, B | SO4 | — |
| 6NC7 | Lipid II flippase murj, inward open conformation | x-ray diffraction | A, B | SO4 | — |
| 6NC8 | Lipid II flippase MurJ, inward occluded conformation | x-ray diffraction | A | NA | — |
| 6NC8 | Lipid II flippase murj, inward occluded conformation | x-ray diffraction | A | NA | — |
| 6NC9 | Lipid II flippase MurJ, outward-facing conformation | x-ray diffraction | A | OLB, NA | — |
| 6NC9 | Lipid II flippase murj, outward-facing conformation | x-ray diffraction | A | OLB, NA | — |
| B7IE18 | AlphaFold monomer V2.0 prediction for lipid II flippase murj (B7IE18) | predicted | A | — | 5 (best 0.79) |
Ligands
Experiment against prediction
- 5T77 chain A against the predicted model B7IE18: TM-score 0.97, RMSD 1.73 Å
- 6NC6 chain B against the predicted model B7IE18: TM-score 0.94, RMSD 2.04 Å
- 6NC6 chain B against the predicted model B7IE18: TM-score 0.94, RMSD 2.04 Å
- 6NC6 chain A against the predicted model B7IE18: TM-score 0.94, RMSD 2.11 Å
- 6NC6 chain A against the predicted model B7IE18: TM-score 0.94, RMSD 2.11 Å
- 6NC7 chain B against the predicted model B7IE18: TM-score 0.94, RMSD 2.44 Å
- 6NC7 chain B against the predicted model B7IE18: TM-score 0.94, RMSD 2.44 Å
- 6NC7 chain A against the predicted model B7IE18: TM-score 0.93, RMSD 2.39 Å
- 6NC7 chain A against the predicted model B7IE18: TM-score 0.93, RMSD 2.39 Å
- 6NC8 chain A against the predicted model B7IE18: TM-score 0.91, RMSD 2.75 Å
Elsewhere
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