UniProt B4RNT1
Leucine--tRNA ligase (B4RNT1)
Leucine--tRNA ligase (UniProt B4RNT1), EC 6.1.1.4: 23 experimental structures on GenesisL1, 7 ligands bound, 46 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- B4RNT1
- Protein
- Leucine--tRNA ligase
- EC
- 6.1.1.4
- Experimental structures
- 23
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 46 · 6 records with a druggable one
Structures
23 records of B4RNT1 in the MolNFT archive: 23 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6Q8A | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with 5'-O-(N-(L-Leucyl)-Sulfamoyl)Cytidine | x-ray diffraction | A | HQ5, ZN, MG | 9 (best 0.77) |
| 6Q8A | Neisseria gonorrhoeae leucyl-tRNA synthetase in complex with 5'-O-(N- (L-leucyl)-SULFAMOYL)CYTIDINE | x-ray diffraction | A | ZN, MG | — |
| 7NTY | Crystal structure of neisseria gonorrhoeae leurs L550A mutant | x-ray diffraction | A | ZN, MG | — |
| 7NTZ | Crystal structure of neisseria gonorrhoeae leurs L550A mutant in complex with the reaction… | x-ray diffraction | A | ZN | — |
| 7NU0 | Crystal Structure of Neisseria gonorrhoeae LeuRS L550A mutant in Complex with ATP and L-leucinol | x-ray diffraction | A | ATP, MG, DCL, ZN | 6 (best 0.76) |
| 7NU1 | Crystal Structure of Neisseria gonorrhoeae LeuRS E169G mutant | x-ray diffraction | A | ZN, MG | 8 (best 0.76) |
| 7NU1 | Crystal structure of neisseria gonorrhoeae leurs E169G mutant | x-ray diffraction | A | ZN, MG | — |
| 7NU2 | Crystal structure of neisseria gonorrhoeae leurs E169G mutant in complex with the reaction… | x-ray diffraction | A | ATP, ZN | — |
| 7NU3 | Crystal Structure of Neisseria gonorrhoeae LeuRS E169G mutant in Complex with ATP and L-leucinol | x-ray diffraction | A | ATP, ZN | — |
| 7NU3 | Crystal structure of neisseria gonorrhoeae leurs E169G mutant in complex with ATP and L-leucinol | x-ray diffraction | A | ATP, ZN | — |
| 7NU4 | Crystal structure of neisseria gonorrhoeae leurs | x-ray diffraction | A | ZN, MG | — |
| 7NU5 | Crystal Structure of Neisseria gonorrhoeae LeuRS in Complex with L-leucine | x-ray diffraction | A | LEU, ZN, MG | 9 (best 0.64) |
| 7NU5 | Crystal structure of neisseria gonorrhoeae leurs in complex with L- leucine | x-ray diffraction | A | ZN, MG | — |
| 7NU6 | Crystal structure of neisseria gonorrhoeae leurs in complex with ATP in conformation 1 | x-ray diffraction | A | ATP, ZN, MG | — |
| 7NU7 | Crystal Structure of Neisseria gonorrhoeae LeuRS in Complex with ATP in Conformation 2 | x-ray diffraction | A | ATP, ZN, MG | 7 (best 0.63) |
| 7NU7 | Crystal structure of neisseria gonorrhoeae leurs in complex with ATP in conformation 2 | x-ray diffraction | A | ATP, ZN | — |
| 7NU8 | Crystal structure of neisseria gonorrhoeae leurs in complex with the reaction intermediate leu-AMP | x-ray diffraction | A | ATP, ZN | — |
| 7NU9 | Crystal structure of neisseria gonorrhoeae leurs in complex with ATP and L-leucinol | x-ray diffraction | A | ATP, MG, ZN | — |
| 7NUA | Crystal structure of neisseria gonorrhoeae leurs L550G mutant | x-ray diffraction | A | ZN, MG | — |
| 7NUB | Crystal structure of neisseria gonorrhoeae leurs L550G mutant in complex with the reaction… | x-ray diffraction | A | ZN, MG | — |
| 7NUC | Crystal structure of neisseria gonorrhoeae leurs L550G mutant in complex with ATP and L-leucinol | x-ray diffraction | A | ATP, MG, ZN | — |
| 7YP8 | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Leucyl-sulfamoyl 3-deazaadenosine | x-ray diffraction | A | JIE, ZN, MG | 7 (best 0.73) |
| B4RNT1 | AlphaFold monomer V2.0 prediction for leucine--tRNA ligase (B4RNT1) | — | — | — |
Ligands
- ZN · Zinc ion · in 22 records
- MG · Magnesium ion · in 16 records
- ATP · Adenosine-5'-triphosphate · in 10 records
- DCL · 2-amino-4-methyl-pentan-1-ol · in 1 record
- HQ5 · 5'-O-(N-(L-Leucyl)-Sulfamoyl)Cytidine · in 1 record
- JIE · [(2R,3S,4R,5R)-5-(4-azanylimidazo[4,5-c]pyridin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl N-[(2S)-2-azanyl-4-methyl-pentanoyl]sulfamate · in 1 record
- LEU · Leucine · in 1 record
Elsewhere
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