UniProt B4DIJ7

Histone-lysine N-methyltransferase (B4DIJ7)

Histone-lysine N-methyltransferase (UniProt B4DIJ7), EC 2.1.1.43: 8 experimental structures on GenesisL1, 5 ligands bound, 9 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt: B4DIJ7
Protein: Histone-lysine N-methyltransferase
EC: 2.1.1.43
Experimental structures: 8
Predicted models: 0
Ligands: 5
Pockets: 9 · 3 records with a druggable one

Structures

8 records of B4DIJ7 in the MolNFT archive: 8 experimental, 0 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
6U9K	MLL1 SET N3861I/Q3867L bound to inhibitor 18 (TC-5153)	x-ray diffraction	A, B	ZN, Q2V	3 (best 0.69)
6U9K	MLL1 set N3861I/Q3867L bound to inhibitor 18 (tc-5153)	x-ray diffraction	A, B	ZN, Q2V	—
6U9M	MLL1 set N3861I/Q3867L bound to inhibitor 16 (tc-5109)	x-ray diffraction	A, B	ZN, Q2M	—
6U9N	MLL1 SET N3861I/Q3867L bound to inhibitor 14 (TC-5139)	x-ray diffraction	A, B	Q34, ZN	3 (best 0.65)
6U9N	MLL1 set N3861I/Q3867L bound to inhibitor 14 (tc-5139)	x-ray diffraction	A, B	Q34, ZN	—
6U9R	MLL1 SET N3861I/Q3867L bound to inhibitor 12 (TC-5140)	x-ray diffraction	A, B	ZN, Q2P	3 (best 0.65)
6U9R	MLL1 set N3861I/Q3867L bound to inhibitor 12 (tc-5140)	x-ray diffraction	A, B	ZN, Q2P	—
7UD5	Complex between MLL1-WRAD and an H2B-ubiquitinated nucleosome	electron microscopy	K	ZN	—

Ligands

ZN · Zinc ion · in 8 records
Q2P · 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(3-chlorophenyl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine · in 2 records
Q2V · 5'-([(3S)-3-amino-3-carboxypropyl]{[1-(3,3-diphenylpropyl)azetidin-3-yl]methyl}amino)-5'-deoxyadenosine · in 2 records
Q34 · 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(4-chlorophenyl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine · in 2 records
Q2M · 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(thiophen-2-yl) methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine · in 1 record

Elsewhere

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