UniProt A7ZUK1
DNA-directed RNA polymerase subunit beta (A7ZUK1)
DNA-directed RNA polymerase subunit beta (UniProt A7ZUK1), EC 2.7.7.6: 19 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 53 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- A7ZUK1
- Protein
- DNA-directed RNA polymerase subunit beta
- EC
- 2.7.7.6
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 53 · 3 records with a druggable one
Structures
20 records of A7ZUK1 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4XSX | Crystal structure of CBR 703 bound to Escherichia coli RNA polymerase holoenzyme | x-ray diffraction | C, I | — | — |
| 4XSX | Crystal structure of cbr 703 bound to escherichia COLI RNA polymerase holoenzyme | x-ray diffraction | C, I | — | — |
| 4XSY | Crystal structure of CBR 9379 bound to Escherichia coli RNA polymerase holoenzyme | x-ray diffraction | C, I | 42T | 18 (best 0.83) |
| 4XSY | Crystal structure of cbr 9379 bound to escherichia COLI RNA polymerase holoenzyme | x-ray diffraction | C, I | — | — |
| 4XSZ | Crystal structure of CBR 9393 bound to Escherichia coli RNA polymerase holoenzyme | x-ray diffraction | C, I | — | — |
| 4XSZ | Crystal structure of cbr 9393 bound to escherichia COLI RNA polymerase holoenzyme | x-ray diffraction | C, I | — | — |
| 4YFK | Escherichia coli RNA polymerase in complex with squaramide compound 8. | x-ray diffraction | C, I | — | — |
| 4YFK | Escherichia COLI RNA polymerase in complex with squaramide compound 8. | x-ray diffraction | C, I | — | — |
| 4YFN | Escherichia coli RNA polymerase in complex with squaramide compound 14… | x-ray diffraction | C, I | — | — |
| 4YFN | Escherichia COLI RNA polymerase in complex with squaramide compound 14… | x-ray diffraction | C, I | — | — |
| 4YFX | Escherichia coli RNA polymerase in complex with Myxopyronin B | x-ray diffraction | C, I | — | — |
| 4YFX | Escherichia COLI RNA polymerase in complex with myxopyronin B | x-ray diffraction | C, I | — | — |
| 4YLN | E. coli Transcription Initiation Complex - 17-bp spacer and 4-nt RNA | x-ray diffraction | C, I, O | — | — |
| 4YLN | E. COLI transcription initiation complex - 17-bp spacer and 4-nt RNA | x-ray diffraction | C, I, O | — | — |
| 4YLO | E. coli Transcription Initiation Complex - 16-bp spacer and 4-nt RNA | x-ray diffraction | C, I, O | — | — |
| 4YLO | E. COLI transcription initiation complex - 16-bp spacer and 4-nt RNA | x-ray diffraction | C, I, O | — | — |
| 4YLP | E. coli Transcription Initiation Complex - 16-bp spacer and 5-nt RNA | x-ray diffraction | C, I, O | — | — |
| 4YLP | E. COLI transcription initiation complex - 16-bp spacer and 5-nt RNA | x-ray diffraction | C, I, O | — | — |
| 8G7E | Cryo-EM structure of 3DVA component 0 of Escherichia coli que-PEC (paused elongation complex) RNA… | electron microscopy | I | — | 16 (best 0.83) |
| A7ZUK1 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit beta (A7ZUK1) | predicted | A | — | 19 (best 0.79) |
Ligands
- 42T · 3-{[(2,6-dichlorophenyl)carbamoyl]amino}-N-hydroxy-N'-phenyl-5-(trifluoromethyl)benzenecarboximidamide · in 1 record
Experiment against prediction
- 4YLN chain C against the predicted model A7ZUK1: TM-score 0.99, RMSD 1.36 Å
- 4YLN chain C against the predicted model A7ZUK1: TM-score 0.99, RMSD 1.36 Å
- 4YLP chain C against the predicted model A7ZUK1: TM-score 0.99, RMSD 1.39 Å
- 4YLP chain C against the predicted model A7ZUK1: TM-score 0.99, RMSD 1.39 Å
- 4XSZ chain C against the predicted model A7ZUK1: TM-score 0.99, RMSD 1.43 Å
- 4XSZ chain C against the predicted model A7ZUK1: TM-score 0.99, RMSD 1.43 Å
- 8G7E chain I against the predicted model A7ZUK1: TM-score 0.99, RMSD 1.44 Å
- 4XSY chain I against the predicted model A7ZUK1: TM-score 0.99, RMSD 1.47 Å
- 4XSX chain C against the predicted model A7ZUK1: TM-score 0.99, RMSD 1.49 Å
- 4XSX chain C against the predicted model A7ZUK1: TM-score 0.99, RMSD 1.49 Å
Elsewhere
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