UniProt A5U6B6
Dihydrofolate reductase (A5U6B6)
Dihydrofolate reductase (UniProt A5U6B6), EC 1.5.1.3: 9 experimental structures on GenesisL1, 10 ligands bound, 11 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A5U6B6
- Protein
- Dihydrofolate reductase
- EC
- 1.5.1.3
- Experimental structures
- 9
- Predicted models
- 0
- Ligands
- 10
- Pockets
- 11 · 3 records with a druggable one
Structures
9 records of A5U6B6 in the MolNFT archive: 9 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6NNE | Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with… | x-ray diffraction | A, B | CO, NDP, KUP, SO4 | — |
| 6NNE | Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis in complex with… | x-ray diffraction | A, B | CO, NDP, KUP, SO4 | — |
| 6VS9 | Mycobacterium tuberculosis dihydrofolate reductase in complex with 3-(piperidin-1-ylmethyl)benzoic… | x-ray diffraction | A, B | RK4, NAP, CO, PO4, SO4 | 3 (best 0.74) |
| 6VS9 | Mycobacterium tuberculosis dihydrofolate reductase in complex with 3- (piperidin-1-YLMETHYL)BENZOIC… | x-ray diffraction | A, B | RK4, NAP, CO, PO4, SO4 | — |
| 6VV7 | Mycobacterium tuberculosis dihydrofolate reductase in complex with JEB136 | x-ray diffraction | A, B | NDP, CO, RPM, PO4, SO4 | 4 (best 0.73) |
| 6VV7 | Mycobacterium tuberculosis dihydrofolate reductase in complex with JEB136 | x-ray diffraction | A, B | NDP, CO, RPM, PO4, SO4 | — |
| 6VV8 | Mycobacterium tuberculosis dihydrofolate reductase in complex with JEB285 | x-ray diffraction | A, B | CO, NAP, RPV | — |
| 6VV9 | Mycobacterium tuberculosis dihydrofolate reductase in complex with JEB300 | x-ray diffraction | A, B | NDP, RQ1, PO4, CO | 4 (best 0.73) |
| 6VV9 | Mycobacterium tuberculosis dihydrofolate reductase in complex with JEB300 | x-ray diffraction | A, B | NDP, RQ1, PO4, CO | — |
Ligands
- CO · Cobalt (II) ion · in 9 records
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 6 records
- PO4 · Phosphate ion · in 6 records
- SO4 · Sulfate ion · in 6 records
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 3 records
- KUP · 5-[(3,4-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine · in 2 records
- RK4 · 3-[(piperidin-1-yl)methyl]benzoic acid · in 2 records
- RPM · 5-[3-(5-methyl-1H-indol-3-yl)propoxy]-1-phenyl-1H-pyrazole-4-carboxylic acid · in 2 records
- RQ1 · 5-[4-(1H-indol-3-yl)butoxy]-1-phenyl-1H-pyrazole-4-carboxylic acid · in 2 records
- RPV · 5-{[3-(1H-indol-3-yl)propanoyl]amino}-1-phenyl-1H-pyrazole-4-carboxylic acid · in 1 record
Elsewhere
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