UniProt A5K0N4
cGMP-dependent protein kinase, putative (A5K0N4)
cGMP-dependent protein kinase, putative (UniProt A5K0N4): 12 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 40 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- A5K0N4
- Protein
- cGMP-dependent protein kinase, putative
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 40 · 4 records with a druggable one
Structures
13 records of A5K0N4 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4RZ7 | Crystal Structure of PVX_084705 with bound PCI32765 | x-ray diffraction | A | — | — |
| 4RZ7 | Crystal structure of PVX_084705 with bound PCI32765 | x-ray diffraction | A | — | — |
| 5DYL | Crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium Vivax - Apo form | x-ray diffraction | A | — | 10 (best 0.74) |
| 5DYL | Crystal structure of the cgmp-dependent protein kinase pkg from plasmodium vivax - apo form | x-ray diffraction | A | — | — |
| 5DZC | Crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium Vivax - AMPPNP bound | x-ray diffraction | A | ANP, UNX, CL, NA | 11 (best 0.73) |
| 5DZC | Crystal structure of the cgmp-dependent protein kinase pkg from plasmodium vivax - amppnp bound | x-ray diffraction | A | — | — |
| 5EZR | Crystal Structure of PVX_084705 bound to compound | x-ray diffraction | A | 4ZS, CL | 9 (best 0.74) |
| 5EZR | Crystal structure of PVX_084705 bound to compound | x-ray diffraction | A | — | — |
| 5F0A | CRYSTAL STRUCTURE OF PVX_084705 WITH BOUND 1-tert-butyl-3-(3-chlorophenoxy)-1H-pyrazolo[3,4-d]pyrimi… | x-ray diffraction | A | 1FB | — |
| 5F0A | Crystal structure of PVX_084705 with bound 1-tert-butyl-3-(3… | x-ray diffraction | A | — | — |
| 5FET | Crystal Structure of PVX_084705 in presence of Compound 2 | x-ray diffraction | A | 1TR | 10 (best 0.75) |
| 5FET | Crystal structure of PVX_084705 in presence of compound 2 | x-ray diffraction | A | — | — |
| A5K0N4 | AlphaFold monomer V2.0 prediction for cgmp-dependent protein kinase (A5K0N4) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 2 records
- 1FB · 1-tert-butyl-3-(3-chlorophenoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-amine · in 1 record
- 1TR · 4-[7-[(dimethylamino)methyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-amine · in 1 record
- 4ZS · N-[5-(3-{2-[(cyclopropylmethyl)amino]pyrimidin-4-yl}-7-[(dimethylamino)methyl]-6-methylimidazo[1,2-a]pyridin-2-yl)-2-fluorophenyl]methanesulfonamide · in 1 record
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
- NA · Sodium ion · in 1 record
- UNX · Unknown atom or ion · in 1 record
Experiment against prediction
- 5FET chain A against the predicted model A5K0N4: TM-score 0.90, RMSD 3.20 Å
- 5FET chain A against the predicted model A5K0N4: TM-score 0.90, RMSD 3.20 Å
- 5DZC chain A against the predicted model A5K0N4: TM-score 0.90, RMSD 3.22 Å
- 5DZC chain A against the predicted model A5K0N4: TM-score 0.90, RMSD 3.22 Å
- 5DYL chain A against the predicted model A5K0N4: TM-score 0.90, RMSD 3.14 Å
- 5DYL chain A against the predicted model A5K0N4: TM-score 0.90, RMSD 3.14 Å
- 5EZR chain A against the predicted model A5K0N4: TM-score 0.90, RMSD 3.24 Å
- 5EZR chain A against the predicted model A5K0N4: TM-score 0.90, RMSD 3.24 Å
- 5F0A chain A against the predicted model A5K0N4: TM-score 0.90, RMSD 3.27 Å
- 5F0A chain A against the predicted model A5K0N4: TM-score 0.90, RMSD 3.27 Å
Elsewhere
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