UniProt A5H660
Histone deacetylase (A5H660)
Histone deacetylase (UniProt A5H660): 58 experimental structures on GenesisL1, 29 ligands bound, 13 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A5H660
- Protein
- Histone deacetylase
- Experimental structures
- 58
- Predicted models
- 0
- Ligands
- 29
- Pockets
- 13 · 1 record with a druggable one
Structures
58 records of A5H660 in the MolNFT archive: 58 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4BZ5 | Crystal structure of Schistosoma mansoni HDAC8 | x-ray diffraction | A, B, C, D | — | — |
| 4BZ5 | Crystal structure of schistosoma mansoni HDAC8 | x-ray diffraction | A, B, C, D | — | — |
| 4BZ6 | Crystal structure of Schistosoma mansoni HDAC8 complexed with SAHA | x-ray diffraction | A, B, C, D | — | — |
| 4BZ6 | Crystal structure of schistosoma mansoni HDAC8 complexed with saha | x-ray diffraction | A, B, C, D | — | — |
| 4BZ7 | Crystal structure of Schistosoma mansoni HDAC8 complexed with M344 | x-ray diffraction | A, B, C, D | — | — |
| 4BZ7 | Crystal structure of schistosoma mansoni HDAC8 complexed with M344 | x-ray diffraction | A, B, C, D | — | — |
| 4BZ8 | Crystal structure of Schistosoma mansoni HDAC8 complexed with J1038 | x-ray diffraction | A, B, C, D | — | — |
| 4BZ8 | Crystal structure of schistosoma mansoni HDAC8 complexed with J1038 | x-ray diffraction | A, B, C, D | — | — |
| 4BZ9 | Crystal structure of Schistosoma mansoni HDAC8 complexed with J1075 | x-ray diffraction | A, B, C, D | — | — |
| 4BZ9 | Crystal structure of schistosoma mansoni HDAC8 complexed with J1075 | x-ray diffraction | A, B, C, D | — | — |
| 4CQF | Crystal structure of Schistosoma mansoni HDAC8 complexed with a mercaptoacetamide inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4CQF | Crystal structure of schistosoma mansoni HDAC8 complexed with a mercaptoacetamide inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 5FUE | Crystal structure of Schistosoma mansoni HDAC8 complexed with 3- benzamido-benzohydroxamate | x-ray diffraction | A, B, C, D | ZN, K, UV4 | — |
| 5FUE | Crystal structure of schistosoma mansoni HDAC8 complexed with 3-benzamido-benzohydroxamate | x-ray diffraction | A, B, C, D | — | — |
| 6FU1 | Crystal structure of schistosoma mansoni HDAC8 complexed with a N- alkyl hydroxamate | x-ray diffraction | A, B, C, D | ZN, K, E7Q | — |
| 6GX3 | Crystal structure of Schistosoma mansoni HDAC8 complexed with an hydroxamate 1 | x-ray diffraction | A, B, C, D | ZN, K, FF2 | — |
| 6GX3 | Crystal structure of schistosoma mansoni HDAC8 complexed with an hydroxamate 1 | x-ray diffraction | A, B, C, D | ZN, K, FF2 | — |
| 6GXA | Crystal structure of Schistosoma mansoni HDAC8 complexed with an hydroxamate 2 | x-ray diffraction | A, B, C, D | ZN, K, TB8 | — |
| 6GXA | Crystal structure of schistosoma mansoni HDAC8 complexed with an hydroxamate 2 | x-ray diffraction | A, B, C, D | ZN, K, TB8 | — |
| 6GXU | Crystal structure of Schistosoma mansoni HDAC8 complexed with an hydroxamate 3 | x-ray diffraction | A, B, C, D | ZN, K, FG8 | — |
| 6GXU | Crystal structure of schistosoma mansoni HDAC8 complexed with an hydroxamate 3 | x-ray diffraction | A, B, C, D | ZN, K, FG8 | — |
| 6GXW | Crystal structure of Schistosoma mansoni HDAC8 complexed with an hydroxamate 4 | x-ray diffraction | A, B, C, D | ZN, K, FGN | — |
| 6GXW | Crystal structure of schistosoma mansoni HDAC8 complexed with an hydroxamate 4 | x-ray diffraction | A, B, C, D | ZN, K, FGN | — |
| 6HQY | Crystal structure of Schistosoma mansoni HDAC8 complexed with PCI-34051 | x-ray diffraction | A, B, C, D | ZN, K, GKW | — |
| 6HQY | Crystal structure of schistosoma mansoni HDAC8 complexed with pci- 34051 | x-ray diffraction | A, B, C, D | ZN, K, GKW | — |
| 6HRQ | Crystal structure of Schistosoma mansoni HDAC8 complexed with NCC-149 | x-ray diffraction | A, B, C, D | ZN, K, GM5 | — |
| 6HRQ | Crystal structure of schistosoma mansoni HDAC8 complexed with ncc-149 | x-ray diffraction | A, B, C, D | ZN, K, GM5 | — |
| 6HSF | Crystal structure of Schistosoma mansoni HDAC8 mutant H292M complexed with PCI-34051 | x-ray diffraction | A, B, C, D | ZN, K, GKW | — |
| 6HSF | Crystal structure of schistosoma mansoni HDAC8 mutant H292M complexed with pci-34051 | x-ray diffraction | A, B, C, D | ZN, K, GKW | — |
| 6HSG | Crystal structure of Schistosoma mansoni HDAC8 H292M mutant complexed with NCC-149 | x-ray diffraction | A, B, C, D | ZN, K, GM5 | — |
| 6HSG | Crystal structure of schistosoma mansoni HDAC8 H292M mutant complexed with ncc-149 | x-ray diffraction | A, B, C, D | ZN, K, GM5 | — |
| 6HSH | Crystal structure of schistosoma mansoni HDAC8 complexed with quisinostat | x-ray diffraction | A, B, C, D | ZN, K, GOK | — |
| 6HSZ | Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 2 | x-ray diffraction | A, B, C, D | ZN, K, GOW | — |
| 6HSZ | Crystal structure of schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 2 | x-ray diffraction | A, B, C, D | ZN, K, GOW | — |
| 6HT8 | Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 3 | x-ray diffraction | A, B, C, D | ZN, K, GQE | — |
| 6HT8 | Crystal structure of schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 3 | x-ray diffraction | A, B, C, D | ZN, K, GQE | — |
| 6HTG | Crystal structure of schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 4 | x-ray diffraction | A, B, C, D | ZN, K, T61 | — |
| 6HTH | Crystal structure of schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 5 | x-ray diffraction | A, B, C, D | ZN, K, GQN | — |
| 6HTI | Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 6 | x-ray diffraction | A, B, C, D | ZN, K, GQW | — |
| 6HTI | Crystal structure of schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 6 | x-ray diffraction | A, B, C, D | ZN, K, GQW | — |
| 6HTT | Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 7 | x-ray diffraction | A, B, C, D | ZN, K, GQZ | — |
| 6HTT | Crystal structure of schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 7 | x-ray diffraction | A, B, C, D | ZN, K, GQZ | — |
| 6HTZ | Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 8 | x-ray diffraction | A, B, C, D | ZN, K, GRK | — |
| 6HTZ | Crystal structure of schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 8 | x-ray diffraction | A, B, C, D | ZN, K, GRK | — |
| 6HU0 | Crystal structure of schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 9 | x-ray diffraction | A, B, C, D | ZN, K, T86 | — |
| 6HU1 | Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 10 | x-ray diffraction | A, B, C, D | ZN, K, GT2 | — |
| 6HU1 | Crystal structure of schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 10 | x-ray diffraction | A, B, C, D | ZN, K, GT2 | — |
| 6HU2 | Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 11 | x-ray diffraction | A, B, C, D | ZN, K, T34 | — |
| 6HU2 | Crystal structure of schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 11 | x-ray diffraction | A, B, C, D | ZN, K, T34 | — |
| 6HU3 | Crystal structure of schistosoma mansoni HDAC8 complexed with a triazole hydroxamate inhibitor | x-ray diffraction | A, B, C, D | ZN, K, GRZ | — |
| 6TLD | Crystal structure of schistosoma mansoni HDAC8 complexed with a triazole hydroxamate inhibitor 2 | x-ray diffraction | A, B, C, D | ZN, K, NK5 | — |
| 7P2S | Crystal structure of schistosoma mansoni HDAC8 in complex with a tricyclic THIENO[3,2-B]INDOLE… | x-ray diffraction | A | ZN, K, 4UI | — |
| 7P2T | Tetartohedrally twinned crystal structure of schistosoma mansoni HDAC8 in complex with a tricyclic… | x-ray diffraction | A, B, C, D | ZN, K, 4VX, CL | — |
| 7P2U | Crystal structure of schistosoma mansoni HDAC8 in complex with a 3- chlorophenyl-spiroindoline… | x-ray diffraction | A | ZN, K, CL, 4WB | — |
| 7P2V | Crystal structure of schistosoma mansoni HDAC8 in complex with a 4- chlorophenyl-spiroindoline… | x-ray diffraction | A | ZN, K, 4XI | — |
| 7P3S | Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 12 | x-ray diffraction | A, B, C, D | ZN, K, 5IB | 13 (best 0.80) |
| 7P3S | Crystal structure of schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 12 | x-ray diffraction | A, B, C, D | ZN, K, 5IB | — |
| 7POZ | Crystal structure of schistosoma mansoni HDAC8 with dmso bound in the active site | x-ray diffraction | A | ZN, K | — |
Ligands
- K · Potassium ion · in 45 records
- ZN · Zinc ion · in 45 records
- GKW · 1-[(4-methoxyphenyl)methyl]-~{N}-oxidanyl-indole-6-carboxamide · in 4 records
- GM5 · ~{N}-oxidanyl-3-[1-(phenylsulfanylmethyl)-1,2,3-triazol-4-yl]benzamide · in 4 records
- 5IB · ~{N}-[2-methoxy-5-(oxidanylcarbamoyl) phenyl]dibenzofuran-4-carboxamide · in 2 records
- CL · Chloride ion · in 2 records
- FF2 · 4-chloranyl-~{N}-oxidanyl-1-benzothiophene-2-carboxamide · in 2 records
- FG8 · (~{E})-3-[2-(4-chlorophenyl)sulfanylphenyl]-~{N}-oxidanyl-prop-2-enamide · in 2 records
- FGN · (~{E})-3-[2-[[2,6-bis(chloranyl)phenyl]methoxy]phenyl]-~{N}-oxidanyl-prop-2-enamide · in 2 records
- GOW · 3-benzamido-4-methyl-~{N}-oxidanyl-benzamide · in 2 records
- GQE · 3-benzamido-4-methoxy-~{N}-oxidanyl-benzamide · in 2 records
- GQW · ~{N}-[2-chloranyl-5-(oxidanylcarbamoyl)phenyl]-1-benzothiophene-7-carboxamide · in 2 records
- GQZ · ~{N}1-oxidanyl-~{N}3-phenyl-benzene-1,3-dicarboxamide · in 2 records
- GRK · 4-methoxy-~{N}-oxidanyl-3-(2-phenylethanoylamino) benzamide · in 2 records
- GT2 · 4-chloranyl-3-[(2,4-dichlorophenyl)carbonylamino]-~{N}-oxidanyl-benzamide · in 2 records
- T34 · 4-methyl-~{N}-oxidanyl-3-[(phenylmethyl)amino]benzamide · in 2 records
- TB8 · (~{E})-3-(2-chlorophenyl)-~{N}-oxidanyl-prop-2-enamide · in 2 records
- 4UI · 5-[[(2R)-7-fluoranyl-2-phenyl-2,3-dihydrothieno[3,2-b]indol-4-yl]methyl]-N-oxidanyl-thiophene-2-carboxamide · in 1 record
- 4VX · 5-[[(2R)-7-bromanyl-2-phenyl-2,3-dihydrothieno[3,2-b]indol-4-yl]methyl]-N-oxidanyl-thiophene-2-carboxamide · in 1 record
- 4WB · 5-[[(2R)-2-(3-chlorophenyl)-1'-methyl-spiro[2h-indole-3,4'-piperidine]-1-yl]methyl]-N-oxidanyl-thiophene-2-carboxamide · in 1 record
- 4XI · 5-[[(2S)-2-(4-chlorophenyl)-1'-methyl-spiro[2h-indole-3,4'-piperidine]-1-yl]methyl]-N-oxidanyl-thiophene-2-carboxamide · in 1 record
- E7Q · ~{N}-[(3~{S})-1-(4-chlorophenyl)-2,5-bis(oxidanylidene)pyrrolidin-3-yl]-~{N}-oxidanyl-hexanamide · in 1 record
- GOK · 2-[4-[[(1-methylindol-3-yl) methylamino]methyl]piperidin-1-yl]-~{N}-oxidanyl-pyrimidine-5-carboxamide · in 1 record
- GQN · 4-methoxy-~{N}-oxidanyl-3-[(4-phenylphenyl) carbonylamino]benzamide · in 1 record
- GRZ · 1-[5-chloranyl-2-(4-fluoranylphenoxy)phenyl]-~{N}-oxidanyl-1,2,3-triazole-4-carboxamide · in 1 record
- NK5 · ~{N}-oxidanyl-1-phenyl-1,2,3-triazole-4-carboxamide · in 1 record
- T61 · 3-benzamido-4-chloranyl-~{N}-oxidanyl-benzamide · in 1 record
- T86 · 3-[(2,4-dichlorophenyl)carbonylamino]-4-methoxy-~{N}-oxidanyl-benzamide · in 1 record
- UV4 · 3-(benzoylamino)-N-oxobenzamide · in 1 record
Elsewhere
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