UniProt A5H025
Ribonuclease L (A5H025)
Ribonuclease L (UniProt A5H025): 16 experimental structures on GenesisL1, 11 ligands bound, 151 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A5H025
- Protein
- Ribonuclease L
- Experimental structures
- 16
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 151 · 8 records with a druggable one
Structures
16 records of A5H025 in the MolNFT archive: 16 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4O1O | Crystal Structure of RNase L in complex with 2-5A | x-ray diffraction | A, B, C, D | 25L | 20 (best 0.76) |
| 4O1O | Crystal structure of RNase L in complex with 2-5A | x-ray diffraction | A, B, C, D | — | — |
| 4O1P | Crystal Structure of RNase L in complex with 2-5A and AMP-PNP | x-ray diffraction | A, B, C, D | ANP, MG, 25L | 20 (best 0.77) |
| 4O1P | Crystal structure of RNase L in complex with 2-5A and AMP-pnp | x-ray diffraction | A, B, C, D | — | — |
| 6M11 | Crystal structure of Rnase L in complex with Sunitinib | x-ray diffraction | a, b | 25A, B49, PO4 | 19 (best 0.79) |
| 6M11 | Crystal structure of RNase L in complex with sunitinib | x-ray diffraction | a, b | 25A, B49, PO4 | — |
| 6M12 | Crystal Structure of Rnase L in complex with SU11652 | x-ray diffraction | a, b | J60, 25L, PO4 | 18 (best 0.78) |
| 6M12 | Crystal structure of RNase L in complex with SU11652 | x-ray diffraction | a, b | J60, 25L, PO4 | — |
| 6M13 | Crystal structure of Rnase L in complex with Toceranib | x-ray diffraction | a, b | BWC, 25L, PO4 | 19 (best 0.79) |
| 6M13 | Crystal structure of RNase L in complex with toceranib | x-ray diffraction | a, b | BWC, 25L, PO4 | — |
| 7DSY | Crystal Structure of RNase L in complex with KM05073 | x-ray diffraction | a, b | 25A, HFX, PO4 | 18 (best 0.77) |
| 7DSY | Crystal structure of RNase L in complex with KM05073 | x-ray diffraction | a, b | 25A, HFX, PO4 | — |
| 7DTS | Crystal structure of RNase L in complex with AC40357 | x-ray diffraction | a, b | 25A, 27K, PO4 | 18 (best 0.78) |
| 7DTS | Crystal structure of RNase L in complex with AC40357 | x-ray diffraction | a, b | 25A, 27K, PO4 | — |
| 7ELW | Crystal structure of RNase L in complex with Myricetin | x-ray diffraction | a, b | 25L, MYC, PO4 | 19 (best 0.76) |
| 7ELW | Crystal structure of RNase L in complex with myricetin | x-ray diffraction | a, b | 25L, MYC, PO4 | — |
Ligands
- PO4 · Phosphate ion · in 12 records
- 25L · [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3R,4R, 5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate · in 8 records
- 25A · 5'-O-monophosphoryladenylyl(2'->5')adenylyl(2'->5') adenosine · in 6 records
- 27K · butyl 4-hydroxybenzoate · in 2 records
- B49 · N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide · in 2 records
- BWC · 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide · in 2 records
- HFX · 1-chloranyl-3-methylsulfinyl-6,7-dihydro-5H-2-benzothiophen-4-one · in 2 records
- J60 · 5-[(E)-(5-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene) methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide · in 2 records
- MYC · 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one · in 2 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
- MG · Magnesium ion · in 1 record
Elsewhere
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