UniProt A4HSF7
Trypanothione reductase (A4HSF7)
Trypanothione reductase (UniProt A4HSF7), EC 1.8.1.12: 21 experimental structures on GenesisL1, 7 ligands bound, 7 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A4HSF7
- Protein
- Trypanothione reductase
- EC
- 1.8.1.12
- Experimental structures
- 21
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 7 · 2 records with a druggable one
Structures
21 records of A4HSF7 in the MolNFT archive: 21 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2JK6 | Structure of Trypanothione Reductase from Leishmania infantum | x-ray diffraction | A, B | — | — |
| 2JK6 | Structure of trypanothione reductase from leishmania infantum | x-ray diffraction | A, B | — | — |
| 2W0H | X ray structure of Leishmania infantum Trypanothione reductase in complex with antimony and NADPH | x-ray diffraction | A, B | — | — |
| 2W0H | X ray structure of leishmania infantum trypanothione reductase in complex with antimony and NADPH | x-ray diffraction | A, B | — | — |
| 2X50 | Crystal structure of Trypanothione reductase from Leishmania infantum in complex with NADPH and… | x-ray diffraction | A, B | — | — |
| 2X50 | Crystal structure of trypanothione reductase from leishmania infantum in complex with NADPH and… | x-ray diffraction | A, B | — | — |
| 2YAU | X-ray structure of the Leishmania infantum tryopanothione reductase in complex with auranofin | x-ray diffraction | A, B | — | — |
| 2YAU | X-ray structure of the leishmania infantum tryopanothione reductase in complex with auranofin | x-ray diffraction | A, B | — | — |
| 4ADW | Crystal structure of leishmania infantum trypanothione reductase in complex with NADPH and… | x-ray diffraction | A, B | — | — |
| 4ADW | Crystal structure of leishmania infantum trypanothione reductase in complex with NADPH and… | x-ray diffraction | A, B | — | — |
| 4APN | Structure of TR from Leishmania infantum in complex with a diarylpirrole-based inhibitor | x-ray diffraction | A, B | — | — |
| 4APN | Structure of tr from leishmania infantum in complex with a diarylpirrole-based inhibitor | x-ray diffraction | A, B | — | — |
| 5EBK | Trypanothione reductase in complex with 6-(sec-butoxy)-2-((3-chlorophenyl)thio)pyrimidin-4-amine | x-ray diffraction | A, B | FAD, RDS, SO4 | — |
| 5EBK | Trypanothione reductase in complex with 6-(sec-butoxy)-2-((3- CHLOROPHENYL)THIO)PYRIMIDIN-4-amine | x-ray diffraction | A, B | — | — |
| 6ER5 | X-ray structure of trypanothione reductase from leishmania infantum in complex with… | x-ray diffraction | A | FAD, BVN, SO4 | — |
| 6I7N | Trypanothione reductase from leismania infantum in complex with TRL156 | x-ray diffraction | A, B | FAD, SO4 | — |
| 6T95 | Trypanothione Reductase from Leismania infantum in complex with 4a | x-ray diffraction | A | FAD, SO4, MWT | 3 (best 0.78) |
| 6T95 | Trypanothione reductase from leismania infantum in complex with TRL149 | x-ray diffraction | A | FAD, SO4, MWT | — |
| 6T97 | Trypanothione reductase from leismania infantum in complex with TRL190 | x-ray diffraction | A | FAD, SO4, MWW | — |
| 6T98 | Trypanothione Reductase from Leishmania infantum in complex with 9a | x-ray diffraction | A | MWZ, SO4, FAD | 4 (best 0.78) |
| 6T98 | Trypanothione reductase from leishmania infantum in complex with TRL187 | x-ray diffraction | A | MWZ, SO4, FAD | — |
Ligands
- FAD · Flavin-adenine dinucleotide · in 8 records
- SO4 · Sulfate ion · in 8 records
- MWT · 1-[2-[5-[4-(4-azanylbutyl)-3-methyl-1,2,3-triazol-3-ium-1-yl]-2-[4-(2-phenylethyl)-1,3-thiazol-2-yl]phenoxy]ethyl]imidazolidin-2-one · in 2 records
- MWZ · 4-[3-methyl-1-[4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]-3-(2-piperidin-4-ylethoxy)phenyl]-1,2,3-triazol-3-ium-4-yl]butan-1-amine · in 2 records
- BVN · 2-(diethylamino)ethyl 4-((3-(4-nitrophenyl)-3-oxopropyl)amino)benzoate · in 1 record
- MWW · 4-[1-[4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]-3-(2-piperidin-4-ylethoxy)phenyl]-1,2,3-triazol-4-yl]butan-1-amine · in 1 record
- RDS · 6-sec-Butoxy-2-[(3-chlorophenyl)sulfanyl]-4-pyrimidinamine · in 1 record
Elsewhere
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