UniProt A0A4P1LXE0
Maltodextrin-binding protein, Induced myeloid leukemia cell differentiation protein Mcl-1 chimera (A0A4P1LXE0)
Maltodextrin-binding protein, Induced myeloid leukemia cell differentiation protein Mcl-1 chimera (UniProt A0A4P1LXE0): 10 experimental structures on GenesisL1, 7 ligands bound, 11 pockets. Binding sites, pockets, druggability…
- UniProt
- A0A4P1LXE0
- Protein
- Maltodextrin-binding protein, Induced myeloid leukemia cell differentiation…
- Experimental structures
- 10
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 11 · 2 records with a druggable one
Structures
10 records of A0A4P1LXE0 in the MolNFT archive: 10 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6XDJ | Crystal structure analysis of mbp-SIN3 | x-ray diffraction | A, B, C, D | BGC, GLC | — |
| 7FBB | De novo design protein D12 with mbp tag | x-ray diffraction | A, B | — | — |
| 7FBC | De novo design protein D22 with mbp tag | x-ray diffraction | A | — | — |
| 7FBD | De novo design protein D53 with mbp tag | x-ray diffraction | B, A | — | — |
| 7KD4 | Structure of the C-terminal domain of the menangle virus phosphoprotein (residues 329 -388), fused… | x-ray diffraction | A, B | GLC, SO4 | — |
| 7KD5 | Structure of the C-terminal domain of the menangle virus phosphoprotein (residues 329 -388), fused… | x-ray diffraction | A | GLC, PIN | — |
| 7VN3 | Crystal structure of MBP-fused BIL1/BZR1 (21-90) in complex with double-stranded DNA contaning… | x-ray diffraction | C, D, A, B | GLC | — |
| 8G3T | MBP-Mcl1 in complex with ligand 12 | x-ray diffraction | A | GLC, YLK | — |
| 8G3U | MBP-Mcl1 in complex with ligand 21 | x-ray diffraction | A | GLC, YKT | 6 (best 0.69) |
| 8G3X | MBP-Mcl1 in complex with ligand 32 | x-ray diffraction | A | GLC, YLF | 5 (best 0.71) |
Ligands
- GLC · alpha-D-glucopyranose · in 7 records
- BGC · beta-D-glucopyranose · in 1 record
- PIN · Piperazine-N,N'-bis(2-ethanesulfonic acid) · in 1 record
- SO4 · Sulfate ion · in 1 record
- YKT · (1'S,3aS,5R,16R,17S,19Z,21R,21aR)-6'-chloro-20-fluoro-21-{[(5S,9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]methyl}-21-methoxy-16,17-dimethyl-2,3,3',3a,4',16,17,18,21,21a-decahydro-2'H,6H,8H-15lambda~6~-spiro[10,12-(ethanediylidene)-15lambda~6~-furo[3,2-i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-7,1'-naphthalene]-13,15,15(4H,14H)-trione · in 1 record
- YLF · N-[(1'S,3aS,5R,15S,17S,19Z,21R,21aR)-6'-chloro-20-fluoro-21-{[(5S,9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]methyl}-21-methoxy-17-methyl-13,15-dioxo-2,3,3',3a,4,4',13,16,17,18,21,21a-dodecahydro-2'H,6H,8H-15lambda~6~-spiro[10,12-(ethanediylidene)-15lambda~6~-furo[3,2-i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-7,1'-naphthalen]-15-yl]-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide · in 1 record
- YLK · (1'S,3aS,5R,16R,17S,19Z,21R,21aR)-6'-chloro-20-fluoro-21-methoxy-16,17-dimethyl-2,3,3',3a,4',16,17,18,21,21a-decahydro-2'H,6H,8H-15lambda~6~-spiro[10,12-etheno-15lambda~6~-furo[3,2-i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-7,1'-naphthalene]-13,15,15(4H,14H)-trione · in 1 record
Experiment against prediction
- 8G3U chain A against the predicted model Q07820: TM-score 0.30, RMSD 2.06 Å
- 8G3T chain A against the predicted model Q07820: TM-score 0.30, RMSD 2.07 Å
- 8G3X chain A against the predicted model Q07820: TM-score 0.30, RMSD 2.09 Å
- 6XDJ chain D against the predicted model P22579: TM-score 0.30, RMSD 6.57 Å
- 6XDJ chain C against the predicted model P22579: TM-score 0.29, RMSD 6.63 Å
- 6XDJ chain B against the predicted model P22579: TM-score 0.27, RMSD 7.47 Å
- 6XDJ chain A against the predicted model P22579: TM-score 0.27, RMSD 7.57 Å
- 7VN3 chain B against the predicted model Q8S307: TM-score 0.19, RMSD 5.62 Å
- 7VN3 chain A against the predicted model Q8S307: TM-score 0.19, RMSD 5.55 Å
- 7VN3 chain D against the predicted model Q8S307: TM-score 0.18, RMSD 5.45 Å
Elsewhere
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