UniProt A0A1Q8UP87
Bifunctional cytochrome P450/NADPH--P450 reductase (A0A1Q8UP87)
Bifunctional cytochrome P450/NADPH--P450 reductase (UniProt A0A1Q8UP87), EC 1.14.14.1, 1.6.2.4: 23 experimental structures on GenesisL1, 13 ligands bound, 122 pockets. Binding sites, pockets, druggability and 3D structures in…
- UniProt
- A0A1Q8UP87
- Protein
- Bifunctional cytochrome P450/NADPH--P450 reductase
- EC
- 1.14.14.1, 1.6.2.4
- Experimental structures
- 23
- Predicted models
- 0
- Ligands
- 13
- Pockets
- 122 · 17 records with a druggable one
Structures
23 records of A0A1Q8UP87 in the MolNFT archive: 23 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5ZLH | Crystal structure of Mn-ProtoporphyrinIX-reconstituted P450BM3 | x-ray diffraction | A, B, C, D | MNH | 20 (best 0.89) |
| 5ZLH | Crystal structure of mn-protoporphyrinix-reconstituted P450BM3 | x-ray diffraction | A, B, C, D | MNH | — |
| 6H1T | Structure of the BM3 heme domain in complex with clotrimazole | x-ray diffraction | A, B, C, D | HEM, CL6 | — |
| 6H1T | Structure of the BM3 heme domain in complex with clotrimazole | x-ray diffraction | A, B, C, D | HEM, CL6 | — |
| 6HN8 | Structure of BM3 heme domain in complex with troglitazone | x-ray diffraction | A, B | HEM, TDZ | — |
| 6HN8 | Structure of BM3 heme domain in complex with troglitazone | x-ray diffraction | A, B | HEM, TDZ | — |
| 7WDD | Crystal structure of the P450 BM3 heme domain mutant F87K in complex with… | x-ray diffraction | A, B | HEM, HOA, IC6, SYN | 5 (best 0.87) |
| 7WDE | Crystal structure of the P450 BM3 heme domain mutant F87L in complex with… | x-ray diffraction | A, B | HEM, IC6, HOA, SYN | — |
| 7WDG | Crystal structure of the P450 BM3 heme domain mutant F87L in complex with… | x-ray diffraction | A, B | HEM, HOA, IPH, IC6 | 6 (best 0.87) |
| 7WDH | Crystal structure of the P450 BM3 heme domain mutant F87A in complex with… | x-ray diffraction | A, B | HEM, HOA, IC6, IPH | 6 (best 0.89) |
| 7WDI | Crystal structure of the P450 BM3 heme domain mutant F87K in complex with… | x-ray diffraction | A, B | HEM, IC6, HOA | 5 (best 0.89) |
| 7WG0 | Structure of the Manganese Protoporphyrin IX-Reconstituted CYP102A1 Heme Domain with… | x-ray diffraction | A, B | XPZ, MNH | 12 (best 0.88) |
| 7WY2 | Structure of the Oxomolybdenum Mesoporphyrin IX-Reconstituted CYP102A1 F87A Mutant Haem Domain with… | x-ray diffraction | A, B | MI9, D0L, SYN, CL | 7 (best 0.85) |
| 7WY3 | Structure of the Oxomolybdenum Mesoporphyrin IX-Reconstituted CYP102A1 F87V Mutant Haem Domain with… | x-ray diffraction | A, B | MI9, GKX, SYN, CL | 11 (best 0.86) |
| 7WY4 | Structure of the CYP102A1 F87A Haem Domain with N-Enanthyl-L-Prolyl-L-Phenylalanine in complex with… | x-ray diffraction | A, B | HEM, D0L, SYN, CL | 9 (best 0.86) |
| 8HON | Crystal structure of the P450 BM3 heme domain mutant F87A in complex with Im-C6-Tyr-Tyr | x-ray diffraction | A, B | HEM | 5 (best 0.89) |
| 8HOO | Crystal structure of the P450 BM3 heme domain mutant F87A in complex with Im-C6-Tyr-Nap | x-ray diffraction | A, B | HEM | 6 (best 0.88) |
| 8HOP | Crystal structure of the P450 BM3 heme domain mutant F87A in complex with Im-C6-Nap-Tyr | x-ray diffraction | A, B | HEM | 6 (best 0.89) |
| 8HOQ | Crystal structure of the P450 BM3 heme domain mutant F87A in complex with Im-C6-Phe(4CF3)-Tyr | x-ray diffraction | A, B | HEM | 5 (best 0.89) |
| 8HOR | Crystal structure of the P450 BM3 heme domain mutant F87A in complex with Im-C6-Phe(4CH3)-Tyr | x-ray diffraction | A, B | HEM | 5 (best 0.89) |
| 8HOS | Crystal structure of the P450 BM3 heme domain mutant F87A in complex with Im-C6-Phe(4NO2)-Tyr | x-ray diffraction | A, B | HEM | 4 (best 0.88) |
| 8HOT | Crystal structure of the P450 BM3 heme domain mutant F87A in complex with NH2-C7-Phe-Phe | x-ray diffraction | A, B | HEM | 3 (best 0.88) |
| 8HOU | Crystal structure of the P450 BM3 heme domain mutant F87A-T268V in complex with Im-N-C4-Phe-Phe | x-ray diffraction | A, B | HEM | 7 (best 0.89) |
Ligands
- HEM · Protoporphyrin IX containing Fe · in 18 records
- HOA · Hydroxyamine · in 5 records
- IC6 · (2S)-2-(6-imidazol-1-ylhexanoylamino)-3-phenyl-propanoic acid · in 5 records
- SYN · ethenylbenzene · in 5 records
- CL · Chloride ion · in 3 records
- MNH · Manganese protoporphyrin IX · in 3 records
- CL6 · 1-[(2-chlorophenyl)(diphenyl)methyl]-1H-imidazole · in 2 records
- D0L · (2S)-2-[[(2S)-1-heptylpyrrolidin-2-yl]carbonylamino]-3-phenyl-propanoic acid · in 2 records
- IPH · Phenol · in 2 records
- MI9 · Oxomolybdenum Mesoporphyrin IX · in 2 records
- TDZ · (5R)-5-(4-{[(2R)-6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl]methoxy}benzyl)-1,3-thiazolidine-2,4-dione · in 2 records
- GKX · (2~{S})-2-(5-cyclohexylpentanoylamino)-3-phenyl-propanoic acid · in 1 record
- XPZ · (2~{S})-2-(hexadecanoylamino)-3-phenyl-propanoic acid · in 1 record
Elsewhere
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