UniProt A0A0L0P1H8
Dihydrofolate reductase (A0A0L0P1H8)
Dihydrofolate reductase (UniProt A0A0L0P1H8), EC 1.5.1.3: 4 experimental structures on GenesisL1, 5 ligands bound, 8 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A0A0L0P1H8
- Protein
- Dihydrofolate reductase
- EC
- 1.5.1.3
- Experimental structures
- 4
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 8 · 3 records with a druggable one
Structures
4 records of A0A0L0P1H8 in the MolNFT archive: 4 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7ZZX | Crystal structure of Candida auris DHFR in apo form | x-ray diffraction | B | — | 1 (best 0.69) |
| 8A0N | Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH | x-ray diffraction | B | NDP, NO3 | — |
| 8A0Z | Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and pyrimethamine | x-ray diffraction | B, A | NDP, CP6, NO3 | 2 (best 0.81) |
| 8CRH | Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and cycloguanil | x-ray diffraction | B, A | VIL, NDP, SO4 | 5 (best 0.75) |
Ligands
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 3 records
- NO3 · Nitrate ion · in 2 records
- CP6 · 5-(4-chloro-phenyl)-6-ethyl-pyrimidine-2,4-diamine · in 1 record
- SO4 · Sulfate ion · in 1 record
- VIL · 5-(4-chlorophenyl)-6,6-dimethyl-1,4-dihydro-1,3,5-triazine-2,4-diamine · in 1 record
Elsewhere
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