UniProt A0A0H2WY27
Penicillin-binding protein 4 (A0A0H2WY27)
Penicillin-binding protein 4 (UniProt A0A0H2WY27): 24 experimental structures on GenesisL1, 8 ligands bound, 38 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A0A0H2WY27
- Protein
- Penicillin-binding protein 4
- Experimental structures
- 24
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 38 · 12 records with a druggable one
Structures
24 records of A0A0H2WY27 in the MolNFT archive: 24 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5TW4 | Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) in complex… | x-ray diffraction | A, B | AI8, ZN, CL, NA | 4 (best 0.74) |
| 5TW4 | Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) in complex… | x-ray diffraction | A, B | AI8, ZN, CL, NA | — |
| 5TW8 | Crystal structure of wild-type S. aureus penicillin binding protein 4 (PBP4) in complex with… | x-ray diffraction | A, B | AI8, ZN, NA | 4 (best 0.70) |
| 5TW8 | Crystal structure of wild-type S. aureus penicillin binding protein 4 (PBP4) in complex with… | x-ray diffraction | A, B | AI8, ZN, NA | — |
| 5TX9 | Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) in complex… | x-ray diffraction | A, B | ZN, RB6, NA | 3 (best 0.70) |
| 5TX9 | Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) in complex… | x-ray diffraction | A, B | ZN, NA | — |
| 5TXI | Crystal structure of wild-type S. aureus penicillin binding protein 4 (PBP4) in complex with… | x-ray diffraction | A, B | RB6, SO4, ZN, CL, NA | 4 (best 0.70) |
| 5TXI | Crystal structure of wild-type S. aureus penicillin binding protein 4 (PBP4) in complex with… | x-ray diffraction | A, B | SO4, ZN, CL, NA | — |
| 5TY2 | Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) in complex… | x-ray diffraction | A, B | NFF, ZN, CL, NA | 3 (best 0.71) |
| 5TY2 | Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) in complex… | x-ray diffraction | A, B | ZN, CL, NA | — |
| 5TY7 | Crystal structure of wild-type S. aureus penicillin binding protein 4 (PBP4) in complex with… | x-ray diffraction | A, B | NFF, ZN, NA | 4 (best 0.71) |
| 5TY7 | Crystal structure of wild-type S. aureus penicillin binding protein 4 (PBP4) in complex with… | x-ray diffraction | A, B | ZN, NA | — |
| 6C3K | Apo crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) | x-ray diffraction | A, B | ZN, NA, CL | 3 (best 0.66) |
| 6C3K | Apo crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) | x-ray diffraction | A, B | ZN, NA, CL | — |
| 6DZ8 | Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (S75C) | x-ray diffraction | A, B | ZN | 5 (best 0.78) |
| 6DZ8 | Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (S75C) | x-ray diffraction | A, B | ZN | — |
| 7KCV | Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) mutant (R200L) | x-ray diffraction | A | ZN | 2 (best 0.52) |
| 7KCV | Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) mutant (R200L) | x-ray diffraction | A | ZN | — |
| 7KCW | Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) mutant (R200L) in complex with… | x-ray diffraction | A | NFF, ZN | 2 (best 0.53) |
| 7KCW | Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) mutant (R200L) in complex with… | x-ray diffraction | A | ZN | — |
| 7KCX | Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) mutant (R200L) in complex with… | x-ray diffraction | A | 1S7, ZN | 2 (best 0.52) |
| 7KCX | Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) mutant (R200L) in complex with… | x-ray diffraction | A | 1S7, ZN | — |
| 7KCY | Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) with cefoxitin | x-ray diffraction | A | 1S7, ZN | 2 (best 0.56) |
| 7KCY | Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) with cefoxitin | x-ray diffraction | A | 1S7, ZN | — |
Ligands
- ZN · Zinc ion · in 24 records
- NA · Sodium ion · in 14 records
- CL · Chloride ion · in 8 records
- 1S7 · (2R)-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl) amino]ethyl}-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid · in 4 records
- AI8 · Ceftaroline, bound form · in 4 records
- NFF · (2R,4S)-2-[(1R)-1-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid · in 3 records
- RB6 · (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyr rolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
Elsewhere
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