UniProt A0A0F6N8X1
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (A0A0F6N8X1)
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (UniProt A0A0F6N8X1), EC 2.1.1.57: 8 experimental structures on GenesisL1, 8 ligands bound, 55 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A0A0F6N8X1
- Protein
- Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
- EC
- 2.1.1.57
- Experimental structures
- 8
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 55 · 8 records with a druggable one
Structures
8 records of A0A0F6N8X1 in the MolNFT archive: 8 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8B07 | Crystal structure of monkeypox virus methyltransferase VP39 in complex with sinefungin | x-ray diffraction | A, B | SFG | 7 (best 0.72) |
| 8CEQ | Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO427 | x-ray diffraction | A, B | UF9 | 6 (best 0.67) |
| 8CER | Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO494 | x-ray diffraction | A, B | UEM | 7 (best 0.69) |
| 8CES | Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO500 | x-ray diffraction | A, B | UH2 | 6 (best 0.68) |
| 8CET | Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO507 | x-ray diffraction | A, B | UGR | 7 (best 0.68) |
| 8CEV | Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO1119 | x-ray diffraction | A, B | UG9 | 6 (best 0.65) |
| 8CGB | Monkeypox virus VP39 in complex with SAH | x-ray diffraction | A, B | SAH | 8 (best 0.69) |
| 8OIV | Monkeypox virus VP39 in complex with SAH and cap0 | x-ray diffraction | A, B | SAH, GTG | 8 (best 0.70) |
Ligands
- SAH · S-adenosyl-L-homocysteine · in 2 records
- GTG · 7-methyl-guanosine-5'-triphosphate-5'-guanosine · in 1 record
- SFG · Sinefungin · in 1 record
- UEM · (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-naphthalen-1-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid · in 1 record
- UF9 · (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-phenylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid · in 1 record
- UG9 · (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-iodanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid · in 1 record
- UGR · (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-quinolin-3-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid · in 1 record
- UH2 · (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-[2-(1~{H}-benzimidazol-2-yl)ethynyl]pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid · in 1 record
Elsewhere
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