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Ligand · ZTX

ZTX · 2-((4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido [5,4-b][1,4]diazepin-6(11H)-one

ZTX, 2-((4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido [5,4-b][1,4]diazepin-6(11H)-one (C24 H26 N6 O2, 430.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
ZTX
Formula
C24 H26 N6 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

ZTX in 2 structures; the first of them:

  • 3ZTX · Aurora kinase selective inhibitors identified using a Taxol-induced checkpoint… · ZTX A1357 · binds LEU99, GLY100, VAL107, ALA120, LYS122, LEU154, LEU170, GLU171 and 8 more
  • 3ZTX · Aurora kinase selective inhibitors identified using a taxol- induced checkpoint… · ZTX A1357 · binds LEU99, GLY100, VAL107, ALA120, LYS122, LEU154, LEU170, GLU171 and 8 more

Residues it binds most

LEU 4, ALA 4, GLU 4, ARG 4, GLY 4, PHE 4, PRO 4, VAL 4, LYS 2 (residue and the binding sites it lines).

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